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Analysis of clinical characteristics and prognosis in patients with recurrent cervical cancer
´ëÇÑ»êºÎÀΰúÇÐȸÁö 2008³â 51±Ç 2È£ p.173 ~ p.181
À̽ÂÈ£(Lee Seung-Ho) - ¼¿ï´ëÇб³ ÀÇ°ú´ëÇÐ »êºÎÀΰúÇб³½Ç
ÀÌÀ¯°æ(Lee Yoo-Kyung) - ¼¿ï´ëÇб³ ÀÇ°ú´ëÇÐ »êºÎÀΰúÇб³½Ç
±èÈñ½Â(Kim Hee-Seoung) - ¼¿ï´ëÇб³ ÀÇ°ú´ëÇÐ »êºÎÀΰúÇб³½Ç
±èÀç¿ø(Kim Jae-Won) - ¼¿ï´ëÇб³ ÀÇ°ú´ëÇÐ »êºÎÀΰúÇб³½Ç
¹Ú³ëÇö(Park Noh-Hyun) - ¼¿ï´ëÇб³ ÀÇ°ú´ëÇÐ »êºÎÀΰúÇб³½Ç
¼Û¿ë»ó(Song Yong-Sang) - ¼¿ï´ëÇб³ ÀÇ°ú´ëÇÐ »êºÎÀΰúÇб³½Ç
°¼ø¹ü(Kang Soon-Beom) - ¼¿ï´ëÇб³ ÀÇ°ú´ëÇÐ »êºÎÀΰúÇб³½Ç
ÀÌÈ¿Ç¥(Lee Hyo-Pyo) - ¼¿ï´ëÇб³ ÀÇ°ú´ëÇÐ »êºÎÀΰúÇб³½Ç
Abstract
¸ñ Àû :
º» ¿¬±¸¿¡¼´Â Àç¹ß¼º ÀڱðæºÎ¾Ï ȯÀÚµéÀÇ ÀÓ»ó °æ°ú¿Í »ýÁ¸·üÀ» È®ÀÎÇÏ°í ¿¹ÈÄ¿¡ ¿µÇâÀ» ÁÙ ¼ö ÀÖ´Â ÀÎÀÚ¿¡ °üÇÏ¿©
ºÐ¼®ÇÏ°íÀÚ ÇÏ¿´´Ù.
¹æ ¹ý :
¼¿ï´ëÇб³º´¿ø »êºÎÀΰú¿¡¼ 1999³â 1¿ùºÎÅÍ 2003³â 12¿ù±îÁö Àç¹ß¼º ÀڱðæºÎ¾ÏÀ¸·Î Áø´Ü¹ÞÀº 63¸íÀÇ È¯ÀÚ¸¦
´ë»óÀ¸·Î ÀÓ»ó ±â·ÏÀ» °íÂûÇÏ¿´´Ù. Kaplan-Meier »ýÁ¸ ºÐ¼®°ú low-rank test¸¦ ÀÌ¿ëÇÏ¿© »ýÁ¸·üÀ» ºñ±³ È®ÀÎÇÏ¿´°í, Cox ºñ·Ê
À§Çè ȸ±Í ºÐ¼®À» ÀÌ¿ëÇÏ¿© Àç¹ß¼º ÀڱðæºÎ¾ÏÀÇ ¿¹ÈÄ ÀÎÀÚ¸¦ ºÐ¼®ÇÏ¿´´Ù.
°á °ú :
¿¬·Éº°·Î´Â 40~49¼¼°¡ 39.7%·Î °¡Àå ¸¹¾Ò°í, FIGO º´±â·Î´Â Ib°¡ 38.1%·Î °¡Àå ¸¹¾Ò´Ù. ¿ø°ÝÀüÀÌ°¡ 29¿¹ (46.0%)ÀÇ
ȯÀÚ¿¡¼ ¹ß»ýÇÏ¿´´Âµ¥, ºÎ´ëµ¿¸Æ ¸²ÇÁÀý·ÎÀÇ ÀüÀÌ°¡ °¡Àå ¸¹¾Ò´Ù. 1Â÷ Ä¡·á ÈÄ Àç¹ß±îÁö ±â°£ÀÎ ¹«º´ »ýÁ¸ ±â°£ÀÇ Áß¾Ó°ªÀº
19°³¿ù (95% CI = 9.5~28.5)À̾ú´Ù. Àç¹ßÇÑ ÀÌÈÄ »ýÁ¸ ±â°£Àº 24°³¿ù (95% CI = 17.4~30.6)À̾ú°í, 5³â »ýÁ¸·üÀº ¾à 20%¿´´Ù.
´Üº¯¼ö ºÐ¼®¿¡¼´Â ¿¬·É, FIGO º´±â, 1Â÷ Ä¡·á½Ã ¼ö¼ú ¿©ºÎ, Àç¹ß ºÎÀ§ÀÇ ¼ö µîÀÌ »ýÁ¸·ü¿¡ À¯ÀÇÇÑ ¿µÇâÀ» ¹ÌÃÆ´Ù. ±×·¯³ª
´Ùº¯¼ö ºÐ¼®¿¡¼´Â FIGO º´±â¿Í Àç¹ß ºÎÀ§ ¼ö¸¸ÀÌ Åë°èÀûÀ¸·Î À¯ÀÇÇÑ ¿¹ÈÄ ÀÎÀÚ¿´´Ù.
°á ·Ð :
Àç¹ß¼º ÀڱðæºÎ¾Ï ȯÀڵ鿡¼ FIGO º´±â¿Í Àç¹ß ºÎÀ§ÀÇ ¼ö¸¸ÀÌ µ¶¸³ÀûÀÎ ¿¹ÈÄ ÀÎÀÚÀÎ °ÍÀ¸·Î »ç·áµÈ´Ù.
Objective : The purpose of this study was to analyze the clinical course and prognosis in patients with recurrent cervical cancer.
Methods : Between January 1999 and December 2003, sixty-three patients were diagnosed as recurrent cervical cancer. The data for clinical characteristics and survival were analyzed retrospectively. Survival after recurrence (SAR) according to prognostic factors was evaluated using Kaplan-Meier analysis with log-rank test. Independent prognostic factors were identified by use of Cox regression model.
Results : The most common stage and age group of the patients were FIGO stage Ib (38.1%) and age between 40 and 49 (39.7%) respectively. Distant metastases were present in 29 patients (46.0%) and the most common site was para-aortic lymph node. Median disease-free survival before the recurrence of cervical cancer was 19 months (95% CI = 9.5 - 28.5). Median SAR was 24 months (95% CI = 17.4 - 30.6) and 5-year survival rate after recurrence was 20.0%. In univariate analysis of the prognostic factors, age, FIGO stage, primary treatment with surgery and number of recurred site were statistically significant. But, multivariate analysis showed that only FIGO stage and the number of recurrent site had prognostic significance.
Conclusion : FIGO stage and number of recurrent site may be independent prognostic factors for the survival in patients with recurrent cervical cancer.
Å°¿öµå
Àç¹ß¼º ÀڱðæºÎ¾Ï, »ýÁ¸·ü, FIGO º´±â, Àç¹ß ºÎÀ§ÀÇ ¼ö, ¿¹ÈÄÀÎÀÚ
Recurrent cervical cancer, Survival after recurrence, FIGO stage, Number of recurrent site, Prognostic factor
KMID :
0358420080510020173
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µîÀçÀú³Î Á¤º¸
À¯È¿¼º°á°ú(Recomendation)
Multivariate analysis showed that only FIGO stage and the number of recurrent site had prognostic significance.