ÀڱðæºÎ ¾ÏÈ°úÁ¤¿¡¼ IL-6 mRNA ¹ßÇöÀÇ ÀÇÀÇ
The clinical significance of Interleukin-6 mRNA expression in cervical intraepithelial neoplasia and cervical cancer
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¹®Çý¼º(Moon Hye-Sung) - ÀÌÈ¿©ÀÚ´ëÇб³ ÀÇ°ú´ëÇÐ »êºÎÀΰúÇб³½Ç
ÃÖÀº¾Æ(Choi Eun-Ah) - ÀÌÈ¿©ÀÚ´ëÇб³ ÀÇ°ú´ëÇÐ »êºÎÀΰúÇб³½Ç
Á¤Çý¿ø(Chung Hye-Won) - ÀÌÈ¿©ÀÚ´ëÇб³ ÀÇ°ú´ëÇÐ »êºÎÀΰúÇб³½Ç
Abstract
¸ñÀû : IL-6´Â ÁÖ¿äÇÑ ¸é¿ª¹ÝÀÀ¿¡ °ü¿©ÇÒ »Ó ¾Æ´Ï¶ó ÀڱðæºÎ¼¼Æ÷ÀÇ ¼ºÀåÀ» ÃËÁøÇÏ´Â ½ÃÅäÄ«ÀÎÀ¸·Î ¾Ë·ÁÁ® ÀÖ´Ù. IL-6´Â ÀڱðæºÎ¾Ï ¼¼Æ÷»ç¸ê¿¡ °ü¿©Çϱ⵵ Çϸç ÀÌ¿Í´Â ¹Ý´ë·Î ÀڱðæºÎ¾Ï¼¼Æ÷ÀÇ ¼ºÀåÀ» ÀÚ±ØÇÑ´Ù°íµµ ÇÑ´Ù. µû¶ó¼ ÀڱðæºÎ Àü¾Ï´Ü°èÀÎ »óÇdz»Á¾¾ç°ú ħÀ±¼º ÀڱðæºÎ¾Ï¿¡¼ IL-6 mRNA ¹ßÇöÀ» Á¤·® ÃøÁ¤ÇÔÀ¸·Î½á IL-6 mRNA°¡ ÀڱðæºÎ ¾ÏÈ°úÁ¤¿¡¼ÀÇ ¿ªÇÒÀ» ±Ô¸íÇÏ°íÀÚ ÇÏ¿´À¸¸ç IL-6 mRNA ¹ßÇö°ú ÀڱðæºÎ¾ÏÀÇ ¿¹ÈÄÀÎÀÚ¿ÍÀÇ »ó°ü°ü°è¸¦ ¾Ë¾Æº¸°íÀÚ ÇÏ¿´´Ù.
¿¬±¸ ¹æ¹ý : 16¸íÀÇ Á¤»ó ÀڱðæºÎ±º°ú 36¸íÀÇ ÀڱðæºÎ »óÇdz»Á¾¾ç±º, 36¸íÀÇ ÀڱðæºÎ¾Ï±º¿¡¼ Á¶Á÷À» äÃëÇÏ¿© RNA¸¦ ÃßÃâÇÏ¿´´Ù. QC PCR·Î IL-6 mRNA ¹ßÇöÀ» ÃøÁ¤ÇÏ¿´´Ù.
°á°ú : ÀڱðæºÎ¿Í ÀڱðæºÎ »óÇdz»Á¾¾ç, ÀڱðæºÎ¾Ï°£¿¡ IL-6 mRNA ¹ßÇöÀÇ Â÷ÀÌ´Â Åë°èÀûÀ¸·Î À¯ÀÇÇÏÁö ¾Ê¾Ò´Ù (p>0.05). ÀڱðæºÎ»óÇdz»Á¾¾çÀÇ Á¤µµ¿¡ µû¶ó IL-6 mRNA ¹ßÇöÀº À¯ÀÇÇÑ Â÷ÀÌ´Â ¾ø¾ú´Ù (p>0.05). ÀڱðæºÎ¾Ï¿¡¼ IL-6 mRNA ¹ßÇöµµ °¢ º´±âº°, Á¶Á÷º´¸®ÇÐÀû À¯Çüº°, ºÐȵµ, Ç÷û SCC-Ag ¼öÄ¡¿¡ µû¶ó Åë°èÀûÀ¸·Î À¯ÀÇÇÑ Â÷ÀÌ´Â ¾ø¾ú´Ù (p>0.05).
°á·Ð : ÀÌ»óÀÇ °á°ú·Î ÀڱðæºÎ ¾ÏÈ°úÁ¤¿¡¼ÀÇ IL-6 mRNA ¹ßÇöÀº Áß¿äÇÑ ¿ªÇÒÀ» ÇÏÁö ¾Ê´Â´Ù°í ÇÏ°Ú´Ù.
Objectives : Interleukin-6 is a pleiotrophic cytokine that is not only a mediator in major immunologic reactions but also a growth factor of keratinocytes. We studied IL-6 mRNA expression in cervical cancer, CIN and normal cervix. And we questioned whether its expression is related to cervical carcinogenesis and other prognostic factors.
Methods: The normal cervical and cervical cancer tissues were taken from healthy women (n=16), and the patients with CIN (n=36) and cervical cancer (n=36). The IL-6 mRNA expression was examined by quantitative competitive PCR after polymerase chain reaction amplification of reverse transcriptase copies of RNA transcripts (RT-PCR).
Results: There was no statistically different among cervical cancer, CIN and normal cervix (p>0.05). The IL-6 mRNA expression was not different according to the grades of CIN. Its expression was not correlated with the stage of cervical cancer, size of tumor, and histopathologic type (p>0.05).
Conclusion: These results suggested that IL-6 mRNA expression might not be associated with the cervical carcinogenesis and prognosis of cervical cancer.
Å°¿öµå
IL-6, ÀڱðæºÎ¾Ï, ÀڱðæºÎ »óÇdz»Á¾¾ç
IL-6, Cervical cancer, CIN, Carcinogenesis
KMID :
0358420020450040659
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µîÀçÀú³Î Á¤º¸
À¯È¿¼º°á°ú(Recomendation)
The IL-6 mRNA expression was not different according to the grades of CIN. Its expression was not correlated with the stage of cervical cancer, size of tumor, and histopathologic type (p>0.05).