Tumor Sprouting in Papillary Thyroid Carcinoma Is Correlated with Lymph Node Metastasis and Recurrence
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ÀÌÀºÁ¤(Lee Eun-Jung) - Korea University College of Medicine Korea University Guro Hospital Department of Pathology
Á¤¿ø°æ(Jung Won-Kyung) - Korea University College of Medicine Korea University Guro Hospital Department of Pathology
¿ìÁ¤¼ö(Woo Jeong-Soo) - Korea University College of Medicine Korea University Guro Hospital Departments of Otorhinolaryngology- Head and Neck Surgery
ÀÌÀ纹(Lee Jae-Bok) - Korea University College of Medicine Korea University Guro Hospital Department of Surgery
½ÅºÀ°æ(Shin Bong-Kyung) - Korea University College of Medicine Korea University Guro Hospital Department of Pathology
±èÇÑ°â(Kim Han-Kyeom) - Korea University College of Medicine Korea University Guro Hospital Department of Pathology
±è¾Ö¸®(Kim Ae-Ree) - Korea University College of Medicine Korea University Guro Hospital Department of Pathology
Abstract
Background: Identification of poor prognostic factors in papillary thyroid carcinoma (PTC) patients is important for the patients¡¯ care and follow-up. We can sometimes see small tumor clusters without desmoplasia and no evidence of lymphatic emboli around the main tumor mass of PTC. We termed this form of tumor clustering, ¡®tumor sprouting,¡¯ and determined whether these tumors correlate with lymphovascular invasion, lymph node metastasis, and recurrence.
Methods: We analyzed a total of 204 cases of papillary thyroid macrocarcinoma. Number, size and distance from the main tumor of the tumor sprouting were observed and analyzed with clinicopathologic characteristics.
Results: Tumor sprouting was observed in 101 patients. Presence of tumor sprouting was significantly associated with positive resection margin (p=.002), lymphovascular invasion (p=.001), lymph node metastasis (p<.001), and recurrence (p=.004). Univariate analysis of recurrence- free survival revealed that tumor multiplicity (p=.037), positive resection margin (p=.007), lymphovascular invasion (p=.004), lymph node metastasis (p<.001), and tumor sprouting (p=.004) were poor prognostic factors. In multivariate analysis, positive resection margin was an independent poor prognostic factor of recurrence.
Conclusions: In conclusion, tumor sprouting is significantly correlated with lymph node metastasis and recurrence. Evaluation of tumor sprouting in PTC patients could be helpful in predicting tumor recurrence or lymph node metastasis.
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Tumor sprouting, Thyroid cancer, papillary, Lymphatic invasion, Lymph node metastasis, Recurrence
KMID :
0357920140480020117
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