Effects of pretreatment with intravenous palonosetron for propofol-remifentanil-based anesthesia in breast and thyroid cancer surgery: a double-blind, randomized, controlled study
Korean Journal of Anesthesiology 2014³â 67±Ç 1È£ p.13 ~ p.19
(Lee Kye-Hyeok) - Korea Cancer Center Hospital Department of Anesthesiology and Pain Medicine
ÀÓ¼º±Ô(Rim Sung-Kyu) - Korea Cancer Center Hospital Department of Anesthesiology and Pain Medicine
ÀÌÁö¿¬(Lee Ji-Yeon) - Korea Cancer Center Hospital Department of Anesthesiology and Pain Medicine
À̼ҿµ(Lee So-Young) - Korea Cancer Center Hospital Department of Anesthesiology and Pain Medicine
À̼ö³²(Lee Su-Nam) - Korea Cancer Center Hospital Department of Anesthesiology and Pain Medicine
ÀÌÀºÁÖ(Lee Eun-Ju) - Korea Cancer Center Hospital Department of Anesthesiology and Pain Medicine
ÀÌÁöÈñ(Lee Ji-Heui) - Korea Cancer Center Hospital Department of Anesthesiology and Pain Medicine
Abstract
Background: We postulated that palonosetron, a novel antiemetic agent, might have the effect of alleviating injection pain from propofol and rocuronium. A double-blind, controlled study was undertaken to evaluate the effect of palonosetron on injection pain during total intravenous anesthesia and postoperative nausea and vomiting (PONV) using propofol-remifentanil in breast and thyroid cancer surgery.
Methods: Sixty patients were randomly allocated to one of two groups. Before injection of propofol and rocuronium, patients in group S (n = 30) received 4 ml of saline and patients in group P (n = 30) received 75 ¥ìg (1.5 ml) of palonosetron mixed with 2.5 ml of saline (n = 30). Patients were evaluated by a blinded anesthesiologist with regard to the scoring of injection pain of propofol, withdrawal response by rocuronium, PONV, shivering, postoperative pain, recall of pain, and overall satisfaction.
Results: The differences between groups in the incidence of injection pain due to propofol and rocuronium were insignificant. However, in group P, the severity of propofol-induced injection pain (3% vs. 33%, P = 0.003) and postoperative pain (P = 0.038) was significantly lower during the first 12 h after surgery. No differences were observed between the groups with respect to PONV, shivering, recall of pain, and overall satisfaction.
Conclusions: We concluded that pretreatment of palonosetron was effective to reduce the severity of propofol-induced injection pain and early postoperative pain, although it did not reduce the incidence of injection pain from propofol and rocuronium.
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Pain, Palonosetron, Postoperative nausea and vomiting, Propofol
KMID :
0356920140670010013
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