Comparison of effects of intraoperative esmolol and ketamine infusion on acute postoperative pain after remifentanil-based anesthesia in patients undergoing laparoscopic cholecystectomy
Korean Journal of Anesthesiology 2014³â 66±Ç 3È£ p.222 ~ p.229
À̹ÌÇö(Lee Mi-Hyeon) - Hallym University College of Medicine Kangnam Sacred Heart Hospital Department of Anesthesiology and Pain Medicine
Á¤¹ÌÈ(Chung Mi-Hwa) - Hallym University College of Medicine Kangnam Sacred Heart Hospital Department of Anesthesiology and Pain Medicine
ÇÑö½Ä(Han Cheol-Sig) - Hallym University College of Medicine Kangnam Sacred Heart Hospital Department of Anesthesiology and Pain Medicine
ÀÌÁ¤Çö(Lee Jeong-Hyun) - Hallym University College of Medicine Kangnam Sacred Heart Hospital Department of Anesthesiology and Pain Medicine
ÃÖ¿µ·æ(Choi Young-Ryong) - Hallym University College of Medicine Kangnam Sacred Heart Hospital Department of Anesthesiology and Pain Medicine
ÃÖÀº¹Ì(Choi Eun-Mi) - Hallym University College of Medicine Kangnam Sacred Heart Hospital Department of Anesthesiology and Pain Medicine
ÀÓÇö°æ(Lim Hyun-Kyung) - Inha University College of Medicine Department of Anesthesiology and Pain Medicine
(Cha Young-Duk) - Inha University College of Medicine Department of Anesthesiology and Pain Medicine
Abstract
Background: Remifentanil is a short-acting drug with a rapid onset that is useful in general anesthesia. Recently, however, it has been suggested that the use of opioids during surgery may cause opioid-induced hyperalgesia (OIH). Researchers have recently reported that esmolol, an ultra-short-acing ¥â1 receptor antagonist, reduces the postoperative requirement for morphine and provides more effective analgesia than the administration of remifentanil and ketamine. Hence, this study was conducted to determine whether esmolol reduces early postoperative pain in patients who are continuously infused with remifentanil for anesthesia during laparoscopic cholecystectomy.
Methods: Sixty patients scheduled to undergo laparoscopic cholecystectomy were randomly divided into three groups. Anesthesia was maintained with sevoflurane and 4 ng/ml (target-controlled infusion) of remifentanil in all patients. Esmolol (0.5 mg/kg) was injected and followed with a continuous dosage of 10 ¥ìg/kg/min in the esmolol group (n = 20). Ketamine (0.3 mg/kg) was injected and followed with a continuous dosage of 3 ¥ìg/kg/min in the ketamine group (n = 20), while the control group was injected and infused with an equal amount of normal saline. Postoperative pain score (visual analog scale [VAS]) and analgesic requirements were compared for the first 6 hours of the postoperative period.
Results: The pain score (VAS) and fentanyl requirement for 15 minutes after surgery were lower in the esmolol and ketamine groups compared with the control group (P < 0.05). There were no differences between the esmolol and ketamine groups.
Conclusions: Intraoperative esmolol infusion during laparoscopic cholecystectomy reduced opioid requirement and pain score (VAS) during the early postoperative period after remifentanil-based anesthesia.
Å°¿öµå
Esmolol, Hyperalgesia, Ketamine, Postoperative pain, Remifentanil, Sevoflurane
KMID :
0356920140660030222
¿ø¹® ¹× ¸µÅ©¾Æ¿ô Á¤º¸
µîÀçÀú³Î Á¤º¸
À¯È¿¼º°á°ú(Recomendation)