Antiemetic effect of propofol administered at the end of surgery in laparoscopic assisted vaginal hysterectomy
Korean Journal of Anesthesiology 2014³â 66±Ç 3È£ p.210 ~ p.215
±èÀ¯Áø(Kim Eu-Gene) - Eulji University College of Medicine Eulji General Hospital Department of Anesthesiology and Pain Medicine
¹ÚÇýÁø(Park Hye-Jin) - Eulji University College of Medicine Eulji General Hospital Department of Anesthesiology and Pain Medicine
°È¿¼®(Kang Hyo-Seok) - Eulji University College of Medicine Eulji General Hospital Department of Anesthesiology and Pain Medicine
ÃÖÁÖ¿¬(Choi Ju-Youn) - Eulji University College of Medicine Eulji General Hospital Department of Anesthesiology and Pain Medicine
ÀÌÇöÁ¤(Lee Hyun-Jeong) - Eulji University College of Medicine Eulji General Hospital Department of Anesthesiology and Pain Medicine
Abstract
Background: Postoperative nausea and vomiting (PONV) commonly occur after general anesthesia, especially in women. In this study, we evaluated the antiemetic efficacy of propofol administered at the end of surgery in highly susceptible patients undergoing a laparoscopy-assisted vaginal hysterectomy.
Methods: A total of 107 women undergoing a laparoscopy-assisted vaginal hysterectomy under general anesthesia were enrolled for this prospective, double-blind, randomized study. Fifteen minutes before the end of surgery, all patients received 50 ¥ìg fentanyl and 1 of following 3 doses; 0.5 mg/kg of propofol (propofol 0.5 group), 1 mg/kg of propofol (propofol 1.0 group), and normal saline (control group). All patients received intravenous patient-controlled analgesia (PCA). Emergence time, a visual analog scale for pain and nausea, duration of postanesthesia care unit (PACU) stay, and frequency of antiemetic use were recorded at 0-2, 2-24, and 24-48 hours postoperatively.
Results: The incidence of nausea significantly lower in the propofol 0.5 and propofol 1.0 groups than in the control group (12.1 vs 14.7 vs 40%). During the first postoperative 2 hours, antiemetics were less frequently administered in the propofol 0.5 and propofol 1.0 groups than in the control group (3.0 vs 5.9 vs 22.5%). Emergence time was slightly longer in the propofol 0.5 and propofol 1.0 groups than in the control group, but there was no significant difference in PACU stay time was observed between the 3 groups.
Conclusions: The results of this study suggest that low-dose propofol administration at the end of surgery may effectively reduce the incidence of PONV within 2 hours postoperatively in highly susceptible women undergoing a laparoscopiy-assisted vaginal hysterectomy and receiving opioid-based PCA.
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Laparoscopy, Opioid, Postoperative nausea and vomiting, Propofol
KMID :
0356920140660030210
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