À¯¼öÁ¾(Yu Su-Jong) - Seoul National University College of Medicine Department of Internal Medicine
¿øÀç°æ(Won Jae-Kyung) - KAIST Department of Bio and Brain Engineering
·ùÇѼ®(Ryu Han-Suk) - Seoul National University College of Medicine Department of Pathology
ÃÖ¿ø¹¬(Choi Won-Mook) - Seoul National University College of Medicine Department of Internal Medicine
Á¶Çý±â(Cho Hye-Ki) - Seoul National University College of Medicine Department of Internal Medicine
Á¶ÀºÁÖ(Cho Eun-Ju) - Seoul National University College of Medicine Department of Internal Medicine
ÀÌÁ¤ÈÆ(Lee Jeong-Hoon) - Seoul National University College of Medicine Department of Internal Medicine
±èÀ±ÁØ(Kim Yoon-Jun) - Seoul National University College of Medicine Department of Internal Medicine
¼°æ¼®(Suh Kyung-Suk) - Seoul National University College of Medicine Department of Surgery
ÀåÀÚÁØ(Jang Ja-June) - Seoul National University College of Medicine Department of Pathology
±èÁ¤¿ë(Kim Chung-Yong) - Seoul National University College of Medicine Department of Internal Medicine
ÀÌÈ¿¼®(Lee Hyo-Suk) - Seoul National University College of Medicine Department of Internal Medicine
À±Á¤È¯(Yoon Jung-Hwan) - Seoul National University College of Medicine Department of Internal Medicine
Á¶±¤Çö(Cho Kwang-Hyun) - KAIST Department of Bio and Brain Engineering
Abstract
Background/Aims: Protein disulfide isomerase (PDI) has been implicated in the survival and progression of some cancer cells, by compensating for endoplasmic reticulum stress by upregulating the protein-folding capacity. However, its prognostic role in patients with hepatocellular carcinoma (HCC) has not been investigated.
Methods: We collected HCC tissues from 83 HCC patients who underwent surgical resection for an immunohistochemical study of PDI. Overall survival (OS) was measured from the date of surgical resection until the date of death from any cause. Radiological progression was evaluated using the modified Response Evaluation Criteria in Solid Tumors in an independent radiological assessment.
Results: PDI expression was found to be increased in human HCC compared to adjacent nontumor tissues. Increased immunopositivity for PDI was associated with a high Edmondson-Steiner grade (p = 0.028). Univariate analysis of patients who had undergone surgical resection for HCC showed that tumor PDI upregulation is a significant risk factor for poor OS (p = 0.016; hazard ratio [HR], 1.980) and time to progression (TTP; p = 0.007; HR, 1.971). Multivariate analyses revealed that high PDI expression was an independent predictor of a shorter TTP (p = 0.015; HR, 1.865) and poor OS (p = 0.012; HR, 2.069).
Conclusions: Upregulated PDI expression is associated with aggressive clinicopathological features of HCC; thus, PDI might serve as an independent prognostic factor and a potential therapeutic target for HCC patients.
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Protein disulfide isomerases, Endoplasmic reticulum stress, Carcinoma, hepatocellular, Prognosis
KMID :
0338420140290050580
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