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Hypersensitivity myocarditis confirmed by cardiac magnetic resonance imaging and endomyocardial biopsy

The Korean Journal of Internal Medicine 2014년 29권 2호 p.236 ~ p.240

박유미(Park Yu-Mi) - Yonsei University Wonju College of Medicine Department of Internal Medicine
안성균(Ahn Sung-Gyun) - Yonsei University Wonju College of Medicine Department of Internal Medicine
(Ko An-Na) - Yonsei University Wonju College of Medicine Department of Internal Medicine
라상호(Ra Sang-Ho) - Yonsei University Wonju College of Medicine Department of Internal Medicine
차재황(Cha Jae-Hwang) - Yonsei University Wonju College of Medicine Department of Internal Medicine
지용관(Jee Yong-Gwan) - Yonsei University Wonju College of Medicine Department of Internal Medicine
이지현(Lee Ji-Hyun) - Yonsei University Wonju College of Medicine Department of Internal Medicine

Abstract

Myocarditis often occurs due to viral infections and postviral immune-mediated responses. Hypersensitivity myocarditis is a rare form of myocarditis. Numerous drugs can induce myocarditis, which is typically reversible after withdrawal of the causative agent. Here, we report a case of hypersensitivity myocarditis that was probably triggered by amoxicillin and that resolved completely with heart failure management as well as discontinuation of the drug. A 68-year-old woman presented with acute chest pain mimicking acute coronary syndromes, but the coronary angiography was normal. A recent history of taking medications, skin rash, and peripheral eosinophilia suggested a diagnosis of hypersensitivity myocarditis, which was confirmed by cardiac magnetic resonance imaging and endomyocardial biopsy.