Being Overweight or Obese Increases the Risk of Progression in Triple-Negative Breast Cancer after Surgical Resection
Journal of Korean Medical Science 2016³â 31±Ç 6È£ p.886 ~ p.891
ÃÖÀ±¼±(Choi Yun-Seon) - Inje University College of Medicine Inje University Busan Paik Hospital Department of Radiation Oncology
¹Ú¼º±¤(Park Sung-Kwang) - Inje University College of Medicine Inje University Busan Paik Hospital Department of Radiation Oncology
¾È±âÁ¤(Ahn Ki-Jung) - Inje University College of Medicine Inje University Pusan Paik Hospital Department of Radiation Oncology
Á¶Èï·¡(Cho Heung-Lae) - Inje University College of Medicine Inje University Pusan Paik Hospital Department of Radiation Oncology
±èÅÂÇö(Kim Tae-Hyun) - Inje University College of Medicine Inje University Pusan Paik Hospital Department of Surgery
À±Çý°æ(Yoon Hye-Kyoung) - Inje University College of Medicine Busan Paik Hospital Department of Pathology
ÀÌÀ±ÇÑ(Lee Yun-Han) - Yonsei University Graduate School Department of Medicine
Abstract
This study aimed to evaluate the association between body mass index (BMI) and progression in triple-negative breast cancer (TNBC). We retrospectively reviewed the medical records of 50 patients with TNBC who underwent breast-conserving surgery or mastectomy between 2007 and 2014. All patients were classified according to BMI (median 23.5 kg/m2, range 17.2?31.6 kg/m2): 31 patients (62%) were classified as being overweight or obese (BMI ¡Ã 23 kg/m2) and 19 patients (38%) were classified as having a normal body weight (BMI < 23 kg/m2). The median follow-up for patients was 31.1 months (range, 6.7?101.9 months). Progression occurred in 7 patients (14%), including 5 ipsilateral breast tumor recurrences, 2 regional lymph node metastases, and 5 distant metastases. Progression was significantly correlated with overweight or obese patients (P = 0.035), while none of the normal weight patients showed progression. The 3-year disease-free survival (DFS) and overall survival (OS) rates were 85.0% and 87.7%, respectively. DFS was significantly reduced in overweight or obese patients compared to that in normal weight patients (P = 0.035). However, OS was not significantly compromised by being overweight or obese (P = 0.134). In conclusion, being overweight or obese negatively affects DFS in TNBC patients.
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Triple-Negative Breast Cancer, Overweight, Obesity, Body Mass Index, Prognosis
KMID :
0191120160310060886
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À¯È¿¼º°á°ú(Recomendation)
Being obese or overweight is closely related to disease progression in TNBC.