Serum Magnesium Level Is Associated with Type 2 Diabetes in Women with a History of Gestational Diabetes Mellitus: The Korea National Diabetes Program Study
Journal of Korean Medical Science 2014³â 29±Ç 1È£ p.84 ~ p.89
¾ç¼¼Á¤(Yang Sae-Jeong) - Daerim St. Marys Hospital Department of Internal Medicine
Ȳ¼ø¿µ(Hwang Soon-Young) - Korea University College of Medicine Department of Biostatistics
¹é¼¼Çö(Baik Sei-Hyun) - Korea University College of Medicine Department of Internal Medicine
³²¹®¼®(Nam Moon-Suk) - Inha University School of Medicine Department of Internal Medicine
ÀÌ°ü¿ì(Lee Kwan-Woo) - Ajou University College of Medicine Department of Internal Medicine
¹Ú¿ë¼ö(Park Yong-Soo) - Hanyang University College of Medicine Department of Internal Medicine
¿ìÁ¤ÅÃ(Woo Jeong-Taek) - Kyung Hee University School of Medicine Department of Internal Medicine
±è¿µ¼³(Kim Young-Seol) - Kyung Hee University College of Medicine Department of Internal Medicine
¹Ú¼±¹Î(Park Sun-Min) - Hoseo University Department of Food and Nutrition
¹Ú¼Ò¿µ(Park So-Young) - Kwandong University College of Medicine Cheil General Hospital & Women¡¯s Healthcare Center Department of Medicine
ÀÓâÈÆ(Yim Chang-Hoon) - Kwandong University College of Medicine Cheil General Hospital & Women¡¯s Healthcare Center Department of Medicine
À±Çö±¸(Yoon Hyun-Koo) - Kwandong University College of Medicine Department of Medicine
±è¼ºÈÆ(Kim Sung-Hoon) - Kwandong University College of Medicine Cheil General Hospital & Women¡¯s Healthcare Center Department of Medicine
Abstract
Gestational diabetes mellitus (GDM) is a strong predictor of postpartum prediabetes and transition to overt type 2 diabetes (T2DM). Although many reports indicate that low magnesium is correlated with deteriorated glucose tolerance, the association between postpartum serum magnesium level and the risk for T2DM in women with a history of GDM has not been evaluated. We analyzed postpartum serum magnesium levels and development of prediabetes and T2DM in women with prior GDM according to American Diabetes Association (ADA) criteria using the Korean National Diabetes Program (KNDP) GDM cohort. During a mean follow-up of 15.6¡¾2.0 months after screening, 116 women were divided into three groups according to glucose tolerance status. Ultimately, eight patients (6.9%) were diagnosed with T2DM, 59 patients (50.9%) with prediabetes, and 49 patients (42.2%) with normal glucose tolerance (NGT) after follow-up. The T2DM group had the lowest serum magnesium level (0.65 [0.63-0.68] mM/L) in the postpartum period, but there was no significant difference between the prediabetes group (0.70 [0.65-0.70] mM/L) and the NGT group (0.70 [0.65-0.70] mM/L) (P=0.073) Multiple logistic regression analysis showed that postpartum HOMA-IR was a significant predictor of both prediabetes and T2DM. Moreover, we found that postpartum serum magnesium level was also a possible predictor for T2DM development. Serum magnesium level in the postpartum period may be a possible predictor for T2DM development in women with a history of GDM.
Å°¿öµå
Diabetes, Gestational, Serum Magnesium, Hypomagnesaemia, Prediabetes, Diabetes Mellitus, Type 2
KMID :
0191120140290010084
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À¯È¿¼º°á°ú(Recomendation)
Low postpartum serum magnesium is a potent risk factor for future T2DM.