Pleomorphic Carcinoma of the Lung with High Serum Beta-human Chorionic Gonadotropin Level and Gynecomastia
Journal of Korean Medical Science 2010년 25권 12호 p.1805 ~ p.1808
(Okutur Kerem) - Bilim University School of Medicine Department of Medical Oncology
(Hasbal Baris) - Bilim University School of Medicine Department of Internal Medicine
(Aydin Kubra) - Bilim University School of Medicine Department of Medical Oncology
(Bozkurt Mustafa) - Bilim University School of Medicine Department of Medical Oncology
(Namal Esat) - Bilim University School of Medicine Department of Medical Oncology
(Oz Buge) - Istanbul University Cerrahpasa School of Medicine Department of Pathology
(Kaynak Kamil) - Istanbul University Cerrahpasa School of Medicine Department of Thoracic Surgery
(Demir Gokhan) - Istanbul University Cerrahpasa School of Medicine Department of Pathology
Abstract
Although gynecomastia is a well-defined paraneoplastic syndrome in patients with non-small cell lung cancer, the association with pleomorphic carcinoma has not been reported. A 50-yr-old man presented with bilateral gynecomastia and elevated serum beta-human chorionic gonadotropin (βhCG) level. Chest tomography showed a mass in the right middle lobe. Right middle lobectomy and mediastinal lymph node dissection were performed. βhCG levels decreased rapidly after surgery. Histological examination revealed pleomorphic carcinoma with positive immunostaining for βhCG. Serum βhCG levels began to increase gradually on postoperatively 4th month. Computed tomography detected recurrence and chemotherapy was started. After second cycle of chemotherapy, βhCG levels decreased dramatically again and tomography showed regression in mass. Patient died 6 months later due to brain metastasis. βhCG expression may be associated with aggressive clinical course and increased risk of recurrence, also βhCG levels may be used to evaluate therapy response in patients with pleomorphic carcinoma.
키워드
Pleomorphic Carcinoma, Lung Neoplasms, Chorionic Gonadotropin, Gynecomastia
KMID :
0191120100250121805
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유효성결과(Recomendation)
After second cycle of chemotherapy, βhCG levels decreased dramatically. βhCG levels may be used to evaluate therapy response in patients with pleomorphic carcinoma.