Pleomorphic Carcinoma of the Lung with High Serum Beta-human Chorionic Gonadotropin Level and Gynecomastia
Journal of Korean Medical Science 2010³â 25±Ç 12È£ p.1805 ~ p.1808
(Okutur Kerem) - Bilim University School of Medicine Department of Medical Oncology
(Hasbal Baris) - Bilim University School of Medicine Department of Internal Medicine
(Aydin Kubra) - Bilim University School of Medicine Department of Medical Oncology
(Bozkurt Mustafa) - Bilim University School of Medicine Department of Medical Oncology
(Namal Esat) - Bilim University School of Medicine Department of Medical Oncology
(Oz Buge) - Istanbul University Cerrahpasa School of Medicine Department of Pathology
(Kaynak Kamil) - Istanbul University Cerrahpasa School of Medicine Department of Thoracic Surgery
(Demir Gokhan) - Istanbul University Cerrahpasa School of Medicine Department of Pathology
Abstract
Although gynecomastia is a well-defined paraneoplastic syndrome in patients with non-small cell lung cancer, the association with pleomorphic carcinoma has not been reported. A 50-yr-old man presented with bilateral gynecomastia and elevated serum beta-human chorionic gonadotropin (¥âhCG) level. Chest tomography showed a mass in the right middle lobe. Right middle lobectomy and mediastinal lymph node dissection were performed. ¥âhCG levels decreased rapidly after surgery. Histological examination revealed pleomorphic carcinoma with positive immunostaining for ¥âhCG. Serum ¥âhCG levels began to increase gradually on postoperatively 4th month. Computed tomography detected recurrence and chemotherapy was started. After second cycle of chemotherapy, ¥âhCG levels decreased dramatically again and tomography showed regression in mass. Patient died 6 months later due to brain metastasis. ¥âhCG expression may be associated with aggressive clinical course and increased risk of recurrence, also ¥âhCG levels may be used to evaluate therapy response in patients with pleomorphic carcinoma.
Å°¿öµå
Pleomorphic Carcinoma, Lung Neoplasms, Chorionic Gonadotropin, Gynecomastia
KMID :
0191120100250121805
¿ø¹® ¹× ¸µÅ©¾Æ¿ô Á¤º¸
µîÀçÀú³Î Á¤º¸
À¯È¿¼º°á°ú(Recomendation)
After second cycle of chemotherapy, ¥âhCG levels decreased dramatically. ¥âhCG levels may be used to evaluate therapy response in patients with pleomorphic carcinoma.