Á¤¼¼Áø(Jeong Se-Jin) - Ewha Womans University Department of Life Sciences
¹ÚÁ¾±æ(Park Jong-Gil) - Weill Cornell Medical College Department of Pathology and Laboratory Medicine
(Kim Sin-Ai) - Ewha Womans University Department of Life Sciences
(Kweon Hyae-Yon) - Ewha Womans University Department of Life Sciences
¼½Â¿î(Seo Seung-Woon) - Ewha Womans University Department of Life Sciences
³ª´ë½Â(Na Dae-Seung) - Korea University School of Life Sciences and Biotechnology
À̵¿È£(Lee Dong-Ho) - Korea University College of Life Sciences and Biotechnology
ȫöÀÌ(Hong Cheol-Yi) - Lifetree Biotech Co. Ltd.
³ªÃµ¼ö(Na Chun-Soo) - Lifetree Biotech Co. Ltd.
µ¿¹Ì¼÷(Dong Mi-Sook) - Korea University School of Life Sciences and Biotechnology
¿À±¸ÅÃ(Oh Goo-Taeg) - Ewha Womans University Department of Life Sciences
Abstract
Rhus verniciflua stokes (RVS) is a popular medicinal plant in oriental medicines which is commonly used to resolve extravasated blood. To elucidate the molecular mechanism of the role of RVS extracts on the regulation of lipid and cholesterol biosynthesis, we investigated whether RVS extract protect the hyperlipidemia in western diet-induced C57BL6/J mice. Mice fed a western diet and additionally RVS extracts was administered orally at a dose of 0.1 or 1 g/kg/day for 2 weeks respectively. Group with higher dose of RVS extract showed a significantly decreased body weight compared with western diet fed mice groups. And total cholesterol, LDL-cholesterol levels and fatty liver formation were also improved especially in group of mice fed western diet supplemented high dose RVS extracts. Next, synthesis of hepatic bile acids were significantly increased in RVS extract fed groups. Furthermore, RVS extracts significantly increase promoter activity of Cyp7a1 via up-regulate the transcriptional expression level of LXR¥á. Our data suggest that RVS extracts could be a potent therapeutic ingredient for prevent a hyperlipidemia via increase of bile acids biosynthesis.
Å°¿öµå
Rhus verniciflua stokes (RVS), Hyperlipidemia, Bile acid biosynthesis, Liver X receptor ¥á (LXR¥á), Cyp7a1
KMID :
0043320150380112049
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À¯È¿¼º°á°ú(Recomendation)
RVS extracts could be a potent therapeutic ingredient for prevent a hyperlipidemia via increase of bile acids biosynthesis.