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Development of the DVH management software for the biologically-guided evaluation of radiotherapy plan

Radiation Oncology Journal
2012년 30권 1호 p.43 ~ p.48
김보경 ( Kim Bo-Kyong ) - 성균관대학교 의과대학 삼성서울병원 방사선종양학과

박희철 ( Park Hee-Chul ) - 성균관대학교 의과대학 삼성서울병원 방사선종양학과
오동렬 ( Oh Dong-Ryol ) - 성균관대학교 의과대학 삼성서울병원 방사선종양학과
신은혁 ( Shin Eun-Hyuk ) - 성균관대학교 의과대학 삼성서울병원 방사선종양학과
안용찬 ( Ahn Yong-Chan ) - 성균관대학교 의과대학 삼성서울병원 방사선종양학과
김진성 ( Kim Jin-Sung ) - 성균관대학교 의과대학 삼성서울병원 방사선종양학과
한영이 ( Han Young-Yih ) - 성균관대학교 의과대학 삼성서울병원 방사선종양학과

Abstract

Purpose: To develop the dose volume histogram (DVH) management software which guides the evaluation of radiotherapy (RT) plan of a new case according to the biological consequences of the DVHs from the previously treated patients.

Materials and Methods: We determined the radiation pneumonitis (RP) as an biological response parameter in order to develop DVH management software. We retrospectively reviewed the medical records of lung cancer patients treated with curative 3-dimensional conformal radiation therapy (3D-CRT). The biological event was defi ned as RP of the Radiation Therapy Oncology Group (RTOG) grade III or more.

Results: The DVH management software consisted of three parts (pre-existing DVH database, graphical tool, and Pinnacle3 script). The pre-existing DVH data were retrieved from 128 patients. RP events were tagged to the specifi c DVH data through retrospective review of patients’ medical records. The graphical tool was developed to present the complication histogram derived from the preexisting database (DVH and RP) and was implemented into the radiation treatment planning (RTP) system, Pinnacle3 v8.0 (Phillips Healthcare). The software was designed for the pre-existing database to be updated easily by tagging the specifi c DVH data with the new incidence of RP events at the time of patients’ follow-up.

Conclusion: We developed the DVH management software as an effective tool to incorporate the phenomenological consequences derived from the pre-existing database in the evaluation of a new RT plan. It can be used not only for lung cancer patients but also for the other disease site with different toxicity parameters.

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학술진흥재단(KCI) KoreaMed 
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