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복막투석 환자에서 Methoxy Polyethylene Glycol-epoetin Beta 피하 투여가 빈혈과 영양지표에 미치는 효과

Effect of Subcutaneous Methoxy Polyethylene Glycol-epoetin Beta on Anemia and Nutritional Indices in Peritoneal Dialysis Patients

한국임상약학회지
2012년 22권 3호 p.202 ~ p.210
김경숙 ( Kim Kyung-Sook ) - 충북대학교 약학대학

이준섭 ( Lee Jun-Seop ) - 충북대학교병원 약제부
김혜영 ( Kim Hye-Young ) - 충북대학교 의과대학 내과학교실
이명구 ( Lee Myung-Koo ) - 충북대학교 약학대학

Abstract

Methoxy polyethylene glycol-epoetin beta (MPG-EPO), a continuous erythropoietin receptor activator, is a new erythropoiesis- stimulating agent with a long half-life. The purpose of this prospective study is to assess the effects of oncemonthly subcutaneous MPG-EPO on hematological responses and nutritional status in peritoneal dialysis patients. Forty four patients undergoing stable peritoneal dialysis were enrolled into the study. Darbepoetin alfa therapy, in peritoneal dialysis patients, was converted to the monthly administration of subcutaneous MPG-EPO for 6 months. The starting dose of MPG-EPO was based on the previous weekly dose of darbepoetin alfa. The dose adjustments were performed to maintain the hemoglobin (Hb) levels in a target range of 10.5-11.0 g/dL. If the Hb levels exceeded 11.0 g/dL, MPGEPO was temporarily interrupted for 1 month. The mean Hb levels were stable with the values of 9.5±1.1 g/dL at baseline, and 10.4±0.9 g/dL at the 6th month after conversion. The mean differences in the changes of Hb levels between the baseline and the 6th month were 0.9±1.4 g/dL, which was statistically significant. However, the mean differences of iron, transferrin saturation and ferritin concentrations were not significant. It did not show significant differences in the changes of the nutritional parameters. These results suggest that the once-monthly subcutaneous administration of MPGEPO for 6 months effectively maintains the Hb levels and nutritional status in peritoneal dialysis patients. Taken together, the once-monthly subcutaneous administration of MPG-EPO was practical and might improve the clinical compliance for the management of renal anemia in peritoneal dialysis patients.

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