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Pazopanib for Non-small Cell Lung Cancer: The First Case Report in Korea

Cancer Research and Treatment
2016년 48권 1호 p.393 ~ p.397
조재민 ( Jo Jae-Min ) - Jeju National University School of Medicine Jeju National University Hospital Department of Internal Medicine

김정호 ( Kim Jung-Ho ) - Gachon University Gil Medical Center Department of Internal Medicine
김지영 ( Kim Ji-Young ) - Jeju National University School of Medicine Jeju National University Hospital Department of Internal Medicine
현창림 ( Hyun Chang-Lim ) - Jeju National University School of Medicine Jeju National University Hospital Department of Pathology
이지영 ( Rhee Ji-Young ) - Jeju National University School of Medicine Jeju National University Hospital Department of Internal Medicine
권정미 ( Kwon Jung-Mi ) - Jeju National University School of Medicine Jeju National University Hospital Department of Internal Medicine
한상훈 ( Han Sang-Hoon ) - Jeju National University School of Medicine Jeju National University Hospital Department of Internal Medicine
김우건 ( Kim Woo-Kun ) - Jeju National University School of Medicine Jeju National University Hospital Department of Internal Medicine

Abstract

Pazopanib is a potent multitargeted tyrosine kinase inhibitor that has been shown to have good efficacy in patients with renal cell carcinoma. A previous phase II trial demonstrated that short-term pazopanib administration was generally well tolerated and showed antitumor activity in patients with early-stage non-small cell lung cancer. Herein, we report on the case of a 66-year-old man with simultaneous metastatic squamous cell carcinoma of the lung and renal cell carcinoma who was treated with pazopanib. The patient showed an unexpected partial response and experienced a 10-month progression-free survival without significant toxicity. To the best of the authors’ knowledge, this is the first report of pazopanib treatment in a non-small cell lung cancer patient in Korea. The results in this patient suggest that pazopanib may be a valid treatment option for advanced non-small cell lung cancer.

키워드

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등재저널 정보
SCI(E) MEDLINE 학술진흥재단(KCI) KoreaMed 대한의학회 회원 
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