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Clinical Usefulness of 18F-FDG PET/CT in the Detection of Early Recurrence in Treated Cervical Cancer Patients with Unexplained Elevation of Serum Tumor Markers

Chonnam Medical Journal
2013년 49권 1호 p.20 ~ p.26
정아리 ( Chong A-Ri ) - Chosun University Hospital Department of Nuclear Medicine

하정민 ( Ha Jung-Min ) - Chosun University Hospital Department of Nuclear Medicine
정신영 ( Jeong Shin-Young ) - Kyungpook National University Hospital Department of Nuclear Medicine
송호천 ( Song Ho-Chun ) - Chonnam National University Hospital Department of Nuclear Medicine
민정준 ( Min Jung-Joon ) - Chonnam National University Hospital Department of Nuclear Medicine
범희승 ( Bom Hee-Seung ) - Chonnam National University Hospital Department of Nuclear Medicine
최호선 ( Choi Ho-Sun ) - Chonnam National University Hospital Department of Obstetrics and Gynecology

Abstract

We investigated the diagnostic value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) for restaging of treated uterine cervix squamous cell cancer with tumor maker elevation that was not explained by other conventional evaluation. We enrolled 32 cases who underwent PET/CT for the restaging of treated cervical cancer with tumor marker elevation that was not explained by recent conventional evaluation. All enrolled cases had squamous cell carcinoma. Increased tumor markers included squamous cell carcinoma antigen (SCC Ag) and carcinoembryonic antigen (CEA). PET/CT findings were determined by pathologic confirmation or clinical follow-up. We compared PET/CT accuracy and clinical parameters including normalization of tumor markers in both the SCC Ag elevation group and the CEA elevation group. The sensitivity, specificity, positive predictive value, and negative predictive value of PET/CT in detecting recurrence were 100%, 83.3%, 82.4%, and 100%, respectively. Accuracy was significantly different between the SCC Ag elevation group and the CEA elevation group (p=0.0169). PET/CT with SCC Ag elevation was more accurate (100%) than PET/CT with CEA elevation (66.7%). Normalization of tumor markers was observed more often in the SCC Ag elevation group than in the CEA elevation group (p=0.0429). PET/CT showed high negative predictive value and sensitivity in the restaging of cervical cancer with unexplained tumor marker elevation. PET/CT was more accurate in patients with SCC Ag elevation than in those with CEA elevation.

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학술진흥재단(KCI) KoreaMed 
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