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Comparison of Clinical Outcomes by Different Renal Replacement Therapy in Patients with End-Stage Renal Disease Secondary to Lupus Nephritis

Korean Journal of Internal Medicine
2011년 26권 1호 p.60 ~ p.67
강석휘 ( Kang Seok-hui ) - Catholic University School of Medicine Department of Internal Medicine

정병하 ( Chung Byung-Ha ) - Catholic University School of Medicine Department of Internal Medicine
최선령 ( Choi Sun-Ryoung ) - Catholic University School of Medicine Department of Internal Medicine
이자영 ( Lee Ja-Young ) - Catholic University School of Medicine Department of Internal Medicine
박훈석 ( Park Hoon-Suk ) - Catholic University School of Medicine Department of Internal Medicine
선인오 ( Sun In-O ) - Catholic University School of Medicine Department of Internal Medicine
최범순 ( Choi Bum-Soon ) - Catholic University School of Medicine Department of Internal Medicine
박철휘 ( Park Cheol-Whee ) - Catholic University School of Medicine Department of Internal Medicine
김영수 ( Kim Yong-Soo ) - Catholic University School of Medicine Department of Internal Medicine
양철우 ( Yang Chul-Woo ) - Catholic University School of Medicine Department of Internal Medicine

Abstract

Background/Aims: Many studies have compared patients with systemic lupus erythematosus (SLE) on renal
replacement therapy (RRT) with non-lupus patients. However, few data are available on the long-term outcome of patients with end-stage renal disease (ESRD) secondary to SLE who are managed by different types of RRTs.

Methods: We conducted a retrospective multicenter study on 59 patients with ESRD who underwent maintenance
RRT between 1990 and 2007 for SLE. Of these patients, 28 underwent hemodialysis (HD), 14 underwent peritoneal dialysis (PD), and 17 patients received kidney transplantation (KT). We analyzed the clinical outcomes in these patients to determine the best treatment modality.

Results: The mean follow-up period was 5 ± 3 years in the HD group, 5 ± 3 years in the PD group, and 10 ± 5
years in the KT group (p = 0.005). Disease flare-up was more common in the HD group than in the KT group (p = 0.012). Infection was more common in the PD and HD groups than in the KT group (HD vs. KT, p = 0.027; PD vs. KT, p = 0.033). Cardiovascular complications were more common in the HD group than in the other groups (p = 0.049). Orthopedic complications were more common in the PD group than in the other groups (p = 0.028). Bleeding was more common in the HD group than in the other groups (p = 0.026). Patient survival was greater in the KT group than in the HD group (p = 0.029). Technique survival was lower in the PD group than in the HD group (p = 0.019).

Conclusions: Among patients with ESRD secondary to SLE, KT had better patient survival and lower complication
rates than HD and lower complication rates than PD. The prognosis between the HD and PD groups was similar. We conclude that if KT is not a viable treatment option, any alternative treatment should take into account the patient’s general condition and preference.

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