Dementia incidence and population-attributable fraction for dementia risk factors in Republic of Korea: a 12-year longitudinal follow-up study of a national cohort.

Hwangbo, Song; Lee, Jin Young; Han, Gyule; Chun, Min Young; Jang, Hyemin; Seo, Sang Won; Na, Duk L; Won, Sungho; Kim, Hee Jin; Lim, Dong Hui
Frontiers in aging neuroscience
2023NA ; 15 ( 4 ) :1126587.
저자 상세정보
Hwangbo, Song -
Lee, Jin Young -
Han, Gyule -
Chun, Min Young -
Jang, Hyemin -
Seo, Sang Won -
Na, Duk L -
Won, Sungho -
Kim, Hee Jin -
Lim, Dong Hui -
ABSTRACT
BACKGROUND: We aimed to investigate the incidence of dementia by age and year as well as the population-attributable fractions (PAFs) for known dementia risk factors in Republic of Korea.

METHODS: A 12-year, nationwide, population-based, retrospective cohort study was conducted. We used customized health information from the National Health Insurance Service (NHIS) data from 2002 to 2017. We analyzed age- and sex-adjusted incidence rates and PAF of dementia for each risk factor such as depression, diabetes, hemorrhagic stroke, ischemic stroke, hypertension, osteoporosis and physical inactivity using Levin's formula.

RESULTS: Of the 794,448 subjects in the dementia-free cohort, 49,524 (6.2%) developed dementia. Dementia incidence showed annual growth from 1.56 per 1,000 person-years in 2006 to 6.94 per 1,000 person-years in 2017. Of all dementia cases, 34,544 subjects (69.8%) were female and 2,479 subjects (5.0%) were early onset dementia. AD dementia accounted for 66.5% of the total dementia incidence. Considering relative risk and prevalence, physical inactivity attributed the greatest to dementia (PAF, 8.1%), followed by diabetes (PAF, 4.2%), and hypertension (PAF, 2.9%). Altogether, the significant risk factors increased the risk of dementia by 18.0% (overall PAF). CONCLUSION: We provided the incidence of dementia and PAFs for dementia risk factors in Republic of Korea using a 12-year, nationwide cohort. Encouraging lifestyle modifications and more aggressive control of risk factors may effectively prevent dementia. CI - Copyright ⓒ 2023 Hwangbo, Lee, Han, Chun, Jang, Seo, Na, Won, Kim and Lim.
keyword
Alzheimer’s disease dementia; dementia; national cohort; population-attributable fraction; risk factor
링크

주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
Considering relative risk and prevalence, physical inactivity attributed the greatest to dementia (PAF, 8.1%), followed by diabetes (PAF, 4.2%), and hypertension (PAF, 2.9%). Altogether, the significant risk factors increased the risk of dementia by 18.0% (overall PAF)
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
DOI
10.3389/fnagi.2023.1126587
KCD코드
ICD 03
건강보험코드