Hwangbo, Song; Lee, Jin Young; Han, Gyule; Chun, Min Young; Jang, Hyemin; Seo, Sang Won; Na, Duk L; Won, Sungho; Kim, Hee Jin; Lim, Dong Hui
Frontiers in aging neuroscience
2023NA ; 15 ( 4 ) :1126587.
PMID : 37520131
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Hwangbo, Song -
Lee, Jin Young -
Han, Gyule -
Chun, Min Young -
Jang, Hyemin -
Seo, Sang Won -
Na, Duk L -
Won, Sungho -
Kim, Hee Jin -
Lim, Dong Hui -
ABSTRACT
BACKGROUND: We aimed to investigate the incidence of dementia by age and year as well as the population-attributable fractions (PAFs) for known dementia risk factors in Republic of Korea.
METHODS: A 12-year, nationwide, population-based, retrospective cohort study was conducted. We used customized health information from the National Health Insurance Service (NHIS) data from 2002 to 2017. We analyzed age- and sex-adjusted incidence rates and PAF of dementia for each risk factor such as depression, diabetes, hemorrhagic stroke, ischemic stroke, hypertension, osteoporosis and physical inactivity using Levin's formula.
RESULTS: Of the 794,448 subjects in the dementia-free cohort, 49,524 (6.2%) developed dementia. Dementia incidence showed annual growth from 1.56 per 1,000 person-years in 2006 to 6.94 per 1,000 person-years in 2017. Of all dementia cases, 34,544 subjects (69.8%) were female and 2,479 subjects (5.0%) were early onset dementia. AD dementia accounted for 66.5% of the total dementia incidence. Considering relative risk and prevalence, physical inactivity attributed the greatest to dementia (PAF, 8.1%), followed by diabetes (PAF, 4.2%), and hypertension (PAF, 2.9%). Altogether, the significant risk factors increased the risk of dementia by 18.0% (overall PAF). CONCLUSION: We provided the incidence of dementia and PAFs for dementia risk factors in Republic of Korea using a 12-year, nationwide cohort. Encouraging lifestyle modifications and more aggressive control of risk factors may effectively prevent dementia. CI - Copyright ¨Ï 2023 Hwangbo, Lee, Han, Chun, Jang, Seo, Na, Won, Kim and Lim.
keyword
Alzheimer¡¯s disease dementia; dementia; national cohort; population-attributable fraction; risk factor
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