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Effect of Selective Serotonin Reuptake Inhibitors on Motor Recovery After Stroke: A Systematic Meta-analysis.

Oh, Ju Sun; Choo, Yoo Jin; Chang, Min Cheol

American journal of physical medicine & rehabilitation
2023May ; 8 ( 6 ) :.

PMID : 37205743

저자 상세정보

Oh, Ju Sun -
Choo, Yoo Jin -
Chang, Min Cheol -

ABSTRACT

OBJECTIVE: We conducted a meta-analysis to determine the effectiveness of SSRIs in improving motor outcomes after stroke. For accuracy, we only included studies in which SSRIs were administered to patients in the recovery phase after stroke (<6 months after stroke). DESIGN: Meta-analyses were conducted according to the tools used to measure motor function. We searched the SCOPUS, PubMed, Embase, and Cochrane Library databases for studies which compared motor recovery in patients who receive SSRI medication in the recovery phase after stroke with a control group that did not receive any SSRI.

RESULTS: A total of 3,715 publications were assessed, and nine studies met the study criteria. The group which received SSRI showed improved Fugl-Meyer Motor Scale and Barthel index scores compared to the control group. However, there was no significant difference in the modified Rankin Scale scores between the SSRI and control groups. The incidence of adverse effects after the administration of SSRIs did not differ from that in the control group. CONCLUSION: Our study showed that the use of SSRI in the recovery phase of stroke improved motor function without significant increase in side effects. CI - Copyright ⓒ 2023 Wolters Kluwer Health, Inc. All rights reserved.

Motor function; Recovery; Selective serotonin reuptake inhibitor; Fluoxetine; Meta-analysis

링크

PubMed

주제코드

주제명(Target field)

연구대상(Population)

연구참여(Sample size)

대상성별(Gender)

질병특성(Condition Category)

연구환경(Setting)

연구설계(Study Design)

연구기간(Period)

중재방법(Intervention Type)

중재명칭(Intervention Name)

키워드(Keyword)

유효성결과(Recomendation)

this study showed that the administration of SSRIs during the recovery phase after stroke (<6 months of stroke onset) is effective in enhancing motor function without a significant increase in adverse effects.

연구비지원(Fund Source)

근거수준평가(Evidence Hierarchy)

출판년도(Year)

참여저자수(Authors)

대표저자

DOI

10.1097/PHM.0000000000002289

KCD코드

ICD 03

건강보험코드