The tumor volume after radical prostatectomy and its clinical impact on the prognosis of patients with localized prostate cancer.

Yuk, Hyeong Dong; Byun, Seok-Soo; Hong, Sung Kyu; Lee, Hakmin
Scientific reports
2022Apr ; 12 ( 1 ) :6003.
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Yuk, Hyeong Dong - Department of Urology, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea.
Byun, Seok-Soo - Department of Urology, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, Korea.
Hong, Sung Kyu - Department of Urology, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, Korea.
Lee, Hakmin - Department of Urology, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, Korea. 65828@snubh.org.
ABSTRACT
We evaluated the contribution of tumor volume (TV) to localized prostate cancer (PCa) patients' prognosis. We retrospectively analyzed the data of 2394 patients who underwent radical prostatectomy (RP) for localized PCa. The effect of TV and tumor prostate ratio (TV/PV) on PCa patients' prognosis was analyzed through Kaplan-Meier and Cox-proportional analysis. The mean prostate volume for all patients was 36.5?±?15.4?cc, and the mean TV was 5.9?±?8.3?cc. A significant positive relationship was observed between the classification by risk group in D' Amico risk classification and the National Comprehensive Cancer Network risk group (P?
keyword
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MESH
Disease-Free Survival, Humans, Male, Neoplasm Recurrence, Local/pathology, Prognosis, *Prostate/pathology/surgery, Prostate-Specific Antigen, Prostatectomy, *Prostatic Neoplasms/pathology/surgery, Retrospective Studies, Seminal Vesicles/pathology, Tumor Burden
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TV was revealed to be an independent prognostic factor in the postoperative biochemical recurrence. Patients with a high number of positive core and longer tumor length were signifcantly related to higher TV.
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DOI
10.1038/s41598-022-09431-2 [doi]
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ICD 03
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