Na, Jae Yoon; Kim, Dongkyun; Kwon, Amy M; Jeon, Jin Yong; Kim, Hyuck; Kim, Chang-Ryul; Lee, Hyun Ju; Lee, Joohyun; Park, Hyun-Kyung
Scientific reports
2021Nov ; 11 ( 1 ) :22353.
PMID : 34785709
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Na, Jae Yoon - Department of Pediatrics, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea.
Kim, Dongkyun - Department of Electrical and Electronic Engineering, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan, 15588, Korea.
Kwon, Amy M - Artificial Intelligence Convergence Research Center, Hanyang University ERICA, Ansan, 15588, Korea.
Jeon, Jin Yong - Department of Medical and Digital Engineering, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea.
Kim, Hyuck - Department of Thoracic and Cardiovascular Surgery, Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea.
Kim, Chang-Ryul - Department of Pediatrics, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea.
Lee, Hyun Ju - Department of Pediatrics, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea.
Lee, Joohyun - Department of Electrical and Electronic Engineering, Hanyang University, 55 Hanyangdaehak-ro, Sangnok-gu, Ansan, 15588, Korea. joohyunlee@hanyang.ac.kr.
Park, Hyun-Kyung - Department of Pediatrics, Hanyang University College of Medicine, 222 Wangsimni-ro, Seongdong-gu, Seoul, 04763, Korea. neopark@hanyang.ac.kr.
ABSTRACT
Despite the many comorbidities and high mortality rate in preterm infants with patent ductus arteriosus (PDA), therapeutic strategies vary depending on the clinical setting, and most studies of the related risk factors are based on small sample populations. We aimed to compare the performance of artificial intelligence (AI) analysis with that of conventional analysis to identify risk factors associated with symptomatic PDA (sPDA) in very low birth weight infants. This nationwide cohort study included 8369 very low birth weight (VLBW) infants. The participants were divided into an sPDA group and an asymptomatic PDA or spontaneously close PDA (nPDA) group. The sPDA group was further divided into treated and untreated subgroups. A total of 47 perinatal risk factors were collected and analyzed. Multiple logistic regression was used as a standard analytic tool, and five AI algorithms were used to identify the factors associated with sPDA. Combining a large database of risk factors from nationwide registries and AI techniques achieved higher accuracy and better performance of the PDA prediction tasks, and the ensemble methods showed the best performances. CI - ??2021. The Author(s).
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