Maternal dyslipidemia and altered cholesterol metabolism in early pregnancy as a risk factor for small for gestational age neonates.

Kim, So Yeon; Lee, Seung Mi; Kwon, Go Eun; Kim, Byoung Jae; Koo, Ja Nam; Oh, Ig Hwan; Kim, Sun Min; Shin, Sue; Kim, Won; Joo, Sae Kyung; Norwitz, Errol R; Jung, Young Mi; Park, Chan-Wook; Jun, Jong Kwan; Choi, Man Ho; Park, Joong Shin
Scientific reports
2021Oct ; 11 ( 1 ) :21066.
ÀúÀÚ »ó¼¼Á¤º¸
Kim, So Yeon -
Lee, Seung Mi -
Kwon, Go Eun -
Kim, Byoung Jae -
Koo, Ja Nam -
Oh, Ig Hwan -
Kim, Sun Min -
Shin, Sue -
Kim, Won -
Joo, Sae Kyung -
Norwitz, Errol R -
Jung, Young Mi -
Park, Chan-Wook -
Jun, Jong Kwan -
Choi, Man Ho -
Park, Joong Shin -
ABSTRACT
We evaluated the relationship between maternal cholesterol levels and its biologically active precursors and metabolites in the first trimester and subsequent risk for small-for-gestational-age birthweight (SGA). This is a secondary analysis of a prospective cohort study which enrolled healthy singleton pregnancies (n?=?1337). Maternal fasting blood was taken in the first trimester and followed up till delivery. The lipid parameters were compared between women who delivered SGA neonates (SGA-group, birthweight?
na
¸µÅ©

ÁÖÁ¦ÄÚµå
ÁÖÁ¦¸í(Target field)
¿¬±¸´ë»ó(Population)
¿¬±¸Âü¿©(Sample size)
´ë»ó¼ºº°(Gender)
Áúº´Æ¯¼º(Condition Category)
¿¬±¸È¯°æ(Setting)
¿¬±¸¼³°è(Study Design)
¿¬±¸±â°£(Period)
ÁßÀç¹æ¹ý(Intervention Type)
ÁßÀç¸íĪ(Intervention Name)
Å°¿öµå(Keyword)
À¯È¿¼º°á°ú(Recomendation)
The risk for SGA was negatively correlated with maternal serum HDL-C quartiles (p = 0.003), and this association remained significant after adjustment for confounding variables. In metabolic signatures of cholesterol, the cholesterol/lathosterol ratio in SGA-group was significantly higher than non-SGA-group [(2.7 (1.6–3.7) vs. 2.1 (1.5–2.9), respectively; p = 0.034)]
¿¬±¸ºñÁö¿ø(Fund Source)
±Ù°Å¼öÁØÆò°¡(Evidence Hierarchy)
ÃâÆdz⵵(Year)
Âü¿©ÀúÀÚ¼ö(Authors)
´ëÇ¥ÀúÀÚ
DOI
10.1038/s41598-021-00270-1
KCDÄÚµå
ICD 03
°Ç°­º¸ÇèÄÚµå