Kim, So Yeon; Lee, Seung Mi; Kwon, Go Eun; Kim, Byoung Jae; Koo, Ja Nam; Oh, Ig Hwan; Kim, Sun Min; Shin, Sue; Kim, Won; Joo, Sae Kyung; Norwitz, Errol R; Jung, Young Mi; Park, Chan-Wook; Jun, Jong Kwan; Choi, Man Ho; Park, Joong Shin
Scientific reports
2021Oct ; 11 ( 1 ) :21066.
PMID : 34702839
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Kim, So Yeon -
Lee, Seung Mi -
Kwon, Go Eun -
Kim, Byoung Jae -
Koo, Ja Nam -
Oh, Ig Hwan -
Kim, Sun Min -
Shin, Sue -
Kim, Won -
Joo, Sae Kyung -
Norwitz, Errol R -
Jung, Young Mi -
Park, Chan-Wook -
Jun, Jong Kwan -
Choi, Man Ho -
Park, Joong Shin -
ABSTRACT
We evaluated the relationship between maternal cholesterol levels and its biologically active precursors and metabolites in the first trimester and subsequent risk for small-for-gestational-age birthweight (SGA). This is a secondary analysis of a prospective cohort study which enrolled healthy singleton pregnancies (n?=?1337). Maternal fasting blood was taken in the first trimester and followed up till delivery. The lipid parameters were compared between women who delivered SGA neonates (SGA-group, birthweight?10th percentile, n?=?107) and women who did not (non-SGA-group, n?=?1230). In addition, metabolic signatures of cholesterol were evaluated in a subset consisting of propensity-score matched SGA (n?=?56) and control group (n?=?56). Among lipid parameters, maternal high-density lipoprotein cholesterol (HDL-C) levels were significantly lower in SGA-group than in non-SGA-group (p?=?0.022). The risk for SGA was negatively correlated with maternal serum HDL-C quartiles (p?=?0.003), and this association remained significant after adjustment for confounding variables. In metabolic signatures of cholesterol, the cholesterol/lathosterol ratio in SGA-group was significantly higher than non-SGA-group [(2.7 (1.6-3.7) vs. 2.1 (1.5-2.9), respectively; p?=?0.034)], suggesting increased endogenous cholesterol biosynthesis. We demonstrated that dyslipidemia and increased cholesterol biosynthesis led to delivery of SGA neonates even in early pregnancy. CI - ??2021. The Author(s).
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