Chen, Meng-Li; Li, Hai-Liang; Guo, Chen-Yang; Zhang, Hao; Yuan, Hang; Li, Zhen; Park, Jung-Hoon; Hu, Hong-Tao
Abdominal radiology (New York)
2021Oct ; 11 ( 10 ) :.
PMID : 34635940
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Chen, Meng-Li -
Li, Hai-Liang -
Guo, Chen-Yang -
Zhang, Hao -
Yuan, Hang -
Li, Zhen -
Park, Jung-Hoon -
Hu, Hong-Tao -
ABSTRACT
PURPOSE: To explore the efficacy and safety of using radiofrequency ablation (RFA) combined with transarterial chemoembolization (TACE) for treating hepatocellular carcinoma (HCC) adjacent to the second hepatic hilus.
METHODS: Between February 2011 and June 2013, 17 patients with HCC underwent combination therapy of TACE and RFA under DSA and CT guidance at our institution. The 17 patients had a total of 23 hepatic tumors, 17 of which were adjacent to the second hepatic hilus.
RESULTS: TACE combined with RFA was performed successfully in all 17 patients with no mortalities or major morbidities. During the 1-month follow-up, tumors of 15 patients (88.2%) were completely ablated after one therapy session and 2 patients had detectable tumor residue. During the follow-up time period (range 6-52?months), local tumor progression developed in 1 patient (1/17, 5.9%) and both local tumor progression and new tumors appeared in 1 patient (1/17, 5.9%). Also, new tumors developed in the untreated portions of the liver in 8 patients (8/17, 47.1%). No distant metastasis was found. Of the 17 patients, 6 (35.3%) died due to tumor progression (3/17, 17.6%), liver failure (2/17, 11.8%), or massive hemorrhage of the gastrointestinal tract (1/17, 5.9%). The overall survival rates were 94.1% (16/17), 82.4% (14/17), and 61.8% (11/17) at 12, 18, and 24?months, respectively, and the median survival time was 25?months (95% CI 18-27). CONCLUSION: Treatment using combination of TACE and RFA is an effective and safe therapeutic strategy for treating HCC with tumor(s) adjacent to the second hepatic hilus. CI - ??2021. The Author(s).
keyword
Hepatocellular carcinoma; Radiofrequency ablation (RFA); Second hepatic hilus; Transarterial chemoembolization (TACE)
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