Kim, Won Tae; Kang, Ho Won; Seo, Sung Pil; Kim, Yong-June; Lee, Sang Cheol; Kim, Wun-Jae; Cho, Bum Sang; Ha, Yun Sok; Kwon, Tae Gyun; Park, Jinsung; Park, Seung Chol; Jeong, Young Beom; Kang, Taek Won; Park, Sung-Woo; Yun, Seok Joong
BMC urology
2021May ; 21 ( 1 ) :85.
PMID : 34039340
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Kim, Won Tae -
Kang, Ho Won -
Seo, Sung Pil -
Kim, Yong-June -
Lee, Sang Cheol -
Kim, Wun-Jae -
Cho, Bum Sang -
Ha, Yun Sok -
Kwon, Tae Gyun -
Park, Jinsung -
Park, Seung Chol -
Jeong, Young Beom -
Kang, Taek Won -
Park, Sung-Woo -
Yun, Seok Joong -
ABSTRACT
Background: Recent reports show that the pre-operative or post-operative skeletal mass index (sarcopenia) affects survival rates for various cancers; however, the link between prostate cancer survival and sarcopenia is unclear. Therefore, this study examined the effect of the pre-operative internal obturator muscle (IOM) mass index on biochemical recurrence (BCR) of prostate cancer (PCa) patients who underwent radical prostatectomy.
Methods: In total, 222 patients, who underwent open, laparoscopic, or robot-assisted radical prostatectomy at seven centers in 2011 and were followed up for 5 years, were enrolled. BCR was examined in the context of pre-operative IOM mass index and BMI.
Results: The mean age of the patients was 67.82 ¡¾ 6.23 years, and the mean pre-operative prostate-specific antigen (PSA) level was 11.61 ¡¾ 13.22 ng/ml. There was no significant difference in baseline characteristics between the low and high IOM mass index groups (p > 0.05). Age, pre-op PSA level, ECE, and T-stage were associated with BCR (p = 0.049, p < 0.001, p = 0.001, p = 0.004, respectively). BMI, prostate volume, Gleason score, resection margin, N-stage, M-stage and IOM mass index was not associated with BCR (p > 0.05).
Conclusions: Pre-operative IOM mass index was not associated with BCR; however, long-term follow-up is necessary to evaluate cancer-specific and overall survival of PCa patients.
keyword
Internal obturator muscle; Prostatic neoplasms; Recurrence; Sarcopenia
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