Prognostic implications of body composition change during primary treatment in patients with ovarian cancer: A retrospective study using an artificial intelligence-based volumetric technique.

Kim, Se Ik; Yoon, Soonho; Kim, Taek Min; Cho, Jeong Yeon; Chung, Hyun Hoon; Song, Yong Sang
Gynecologic oncology
2021May ; 21 ( 1 ) :.
저자 상세정보
Kim, Se Ik -
Yoon, Soonho -
Kim, Taek Min -
Cho, Jeong Yeon -
Chung, Hyun Hoon -
Song, Yong Sang -
ABSTRACT
OBJECTIVE: To investigate the impact of changes in body composition during primary treatment on survival outcomes in patients with epithelial ovarian cancer (EOC).

METHODS: We retrospectively identified patients diagnosed with EOC between 2010 and 2019. Using an artificial intelligence-based tool, the volumes of skeletal muscle, visceral fat, and subcutaneous fat were measured automatically at the waist level from pre-treatment and post-treatment computed tomography scans. Associations between changes in body mass index (BMI) and volume of each body composition component and survival outcomes were evaluated.

RESULTS: A total of 208 patients were included. A significant decrease in BMI and waist volumes of skeletal muscle and visceral fat was observed during the primary treatment. Patients with BMI loss ??% showed significantly worse progression-free survival (PFS) and overall survival (OS) than those with BMI loss <5%. In multivariate analyses adjusting for clinicopathologic factors, BMI loss ??% was identified as an independent poor prognostic factor for PFS (adjusted HR, 1.565; 95% CI, 1.074-2.280; P = 0.020) and OS (adjusted HR, 2.754; 95% CI, 1.382-5.488; P = 0.004). Meanwhile, both muscle loss ??0% and visceral fat loss ??0% were associated with an increased mortality rate but did not affect disease recurrence. In multivariate analyses, muscle loss ??0% (adjusted HR, 2.069; 95% CI, 1.055-4.058; P = 0.034) and visceral fat loss ??0% (adjusted HR, 2.292; 95% CI, 1.023-5.133; P = 0.044) were poor prognostic factors for OS. Consistent results were observed in the advanced-stage disease subgroup (n = 173).

CONCLUSIONS: Changes in BMI and waist volume of skeletal muscle and visceral fat were associated with survival outcomes in patients with EOC. CI - Copyright ??2021 Elsevier Inc. All rights reserved.
keyword
Body composition; Body mass index; Epithelial ovarian cancer; Muscle mass; Ovarian neoplasms; Prognosis; Survival; Visceral fat
MESH
링크

주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
This study investigated impact of changes in body composition during primary treatment on prognosis of epithelial ovarian cancer. • An artificial intelligence-based volumetric technique was applied on each patient's pre- and post-treatment CT scans; Patients with BMI loss ≥5% showed significantly worse progression-free survival (PFS) and overall survival (OS) than those with BMI loss <5%.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
DOI
10.1016/j.ygyno.2021.05.004
KCD코드
ICD 03
건강보험코드