Lee, Jong Yoon; Jang, Jin Seok
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology
2021Feb ; 9 ( 2 ) :.
PMID : 33551349
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Lee, Jong Yoon - Department of Internal Medicine, Dong-A University College of Medicine, Busan 49201, South Korea.
Jang, Jin Seok - Department of Internal Medicine, Dong-A University College of Medicine, Busan 49201,
ABSTRACT
BACKGROUND AND STUDY AIMS: Endoscopic submucosal dissection (ESD) is the most effective treatment for early gastric cancer or gastric adenoma. However, ESD results in iatrogenic ulcers and postoperative bleeding from ulcers. This study aimed to evaluate the effect of using a proton pump inhibitor (PPI) alone, a PPI?+?rebamipide combination therapy, and an H2 receptor antagonist (H2RA)?+?rebamipide combination therapy on ulcer healing after ESD. PATIENTS AND
METHODS: A total of 204 patients who underwent ESD from April 2014 to July 2017 at Dong-A University Hospital were randomly assigned to the following groups: PPI-alone group, PPI?+?rebamipide combination therapy group, and H2RA?+?rebamipide combination therapy group. However, only 156 patients were studied since we excluded those who were lost to follow-up or had diseases other than early gastric cancer or gastric adenoma. Twenty-eight days after ESD, we evaluated the ulcer residual ratio, S stage rates, ulcer bleeding ratio, and gastric pH.
RESULTS: This study included 156 patients (PPI-alone group: 52 patients; PPI?+?rebamipide group: 52 patients; H2RA?+?rebamipide group: 52 patients). The ulcer residual ratios were 24.3?±?14.2%, 17.0?±?12.1%, and 21.0?±?13.8% in the PPI alone, PPI?+?rebamipide, and H2RA?+?rebamipide groups, respectively (P?=?0.048).
CONCLUSIONS: PPI?+?rebamipide was more effective in reducing the ulcer residual ratio after ESD. There was no statistical difference in ulcer stage and delayed bleeding after ESD among the groups. These findings showed that PPI?+?rebamipide had limited benefits after ESD. CI - Copyright ??2020 Pan-Arab Association of Gastroenterology. Published by Elsevier B.V. All rights reserved.
keyword
Anti-ulcer agents; Endoscopic submucosal dissection; Gastrointestinal hemorrhage; Proton pump inhibitors; Ulcer
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