Park, Yewan; Kim, Tae Jun; Lee, Hyuk; Yoo, Heejin; Sohn, Insuk; Min, Yang Won; Min, Byung-Hoon; Lee, Jun Haeng; Rhee, Poong-Lyul; Kim, Jae J
Helicobacter
2021Jan ; 29 ( 1 ) :e12783.
PMID : 33508177
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Park, Yewan - Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Kim, Tae Jun - Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of
Lee, Hyuk - Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of
Yoo, Heejin - Statistics and Data Center, Samsung Medical Center, Sungkyunkwan University School
Sohn, Insuk - Statistics and Data Center, Samsung Medical Center, Sungkyunkwan University School
Min, Yang Won - Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of
Min, Byung-Hoon - Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of
Lee, Jun Haeng - Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of
Rhee, Poong-Lyul - Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of
Kim, Jae J - Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of
ABSTRACT
BACKGROUND: Previous studies have suggested a relationship between Helicobacter pylori infection and dyslipidemia; however, large-scale longitudinal studies have not elucidated this association. This study assessed the longitudinal effects of H. pylori infection and eradication on lipid profiles in a large cohort.
METHODS: This cohort study included 2,626 adults without dyslipidemia at baseline, who participated in a repeated, regular health-screening examination, which included upper gastrointestinal endoscopy, between January 2009 and December 2018. The primary outcome was incident dyslipidemia at follow-up.
RESULTS: During the 10,324 person-years of follow-up, participants with persistent H. pylori infection had a higher incidence rate (130.5 per 1,000 person-years) of dyslipidemia than those whose infections had been successfully controlled (98.1 per 1,000 person-years). In a multivariable model adjusted for age, sex, waist circumference, smoking status, alcohol intake, and education level, the H. pylori eradication group was associated with a lower risk of dyslipidemia than the persistent group (HR, 0.85; 95% CI, 0.77-0.95; p?=?0.004). The association persisted after further adjustment for baseline levels of low-density and high-density lipoprotein cholesterol (HR, 0.87; 95% CI, 0.79-0.97; p?=?0.014).
CONCLUSIONS: H. pylori infection may play a pathophysiologic role in the development of dyslipidemia, whereas H. pylori eradication might decrease the risk of dyslipidemia. CI - ??2021 John Wiley & Sons Ltd.
keyword
Helicobacter pylori; cohort study; dyslipidemia; eradication
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