KCTBASE

Factors Associated with the Delayed Termination of Viral Shedding in COVID-19 Patients with Mild Severity in South Korea.

Kim, Bongyoung; Sohn, Jang Wook; Nam, Soomin; Sohn, Jang Won; Choi, Won Suk; Kim, Hyoung Seop

Medicina (Kaunas, Lithuania)
2020Nov ; 56 ( 12 ) :.

PMID : 33260421

저자 상세정보

Kim, Bongyoung - Department of Internal Medicine, College of Medicine, Hanyang University, Seoul 04763, Korea.
Sohn, Jang Wook - Department of Internal Medicine, College of Medicine, Korea University, Seoul 02841,
Nam, Soomin - Department of General Surgery, National Health Insurance Ilsan Hospital, Goyang
Sohn, Jang Won - Department of Internal Medicine, College of Medicine, Hanyang University, Seoul
Choi, Won Suk - Department of Internal Medicine, College of Medicine, Korea University, Seoul 02841,
Kim, Hyoung Seop - Department of Physical Medicine and Rehabilitation, National Health Insurance Ilsan

ABSTRACT

Background and objectives: We aimed to analyze factors associated with the period of viral shedding in patients with confirmed COVID-19 who experienced only mild symptoms. Materials and methods: We conducted a multicenter retrospective study from three community treatment centers (CTCs) of South Korea. All patients included were admitted to the three centers before 31 March 2020. We collected data about clinical characteristics and the result of real-time reverse transcription polymerase chain reaction (RT-PCR). Results: Viral shedding was terminated within 32 days and 36 days in 75% and 90% of patients, respectively (range: 8-49 days). The mean period of viral shedding was 23.8 짹 8.7 days. In the multivariate Cox proportional hazards regression analysis, the existence of underlying comorbidities lowered the probability of the termination of viral shedding (HR = 0.561, 95% CI 0.388-0.812). Female sex and presence of COVID-19-associated symptoms also lowered the probability, but the significance was marginal. Conclusions: The existence of underlying comorbidities was associated with delayed termination of viral shedding in COVID-19 patients with mild severity.

keyword

COVID-19; Republic of Korea; coronavirus; extended care facilities; isolation

링크

PubMed

주제코드

주제명(Target field)

연구대상(Population)

연구참여(Sample size)

대상성별(Gender)

질병특성(Condition Category)

연구환경(Setting)

연구설계(Study Design)

연구기간(Period)

중재방법(Intervention Type)

중재명칭(Intervention Name)

키워드(Keyword)

유효성결과(Recomendation)

This study found that the factor that most affected the prolonged viral shedding was existence of underlying comorbidities. Of patients with mild COVID-19, viral shedding was terminated within 36 days in 90% of patients and the existence of underlying comorbidities was associated with the delayed termination of viral shedding.

연구비지원(Fund Source)

근거수준평가(Evidence Hierarchy)

출판년도(Year)

참여저자수(Authors)

대표저자

DOI

10.3390/medicina56120659

KCD코드

ICD 03

건강보험코드