Jang, Sukbin; Rhee, Ji-Young; Wi, Yu Mi; Jung, Bo Kyeung
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
2020Nov ; 91 ( 11 ) :.
PMID : 33160066
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Jang, Sukbin - Division of Infectious Diseases, Department of Medicine, Dankook University College of Medicine, Cheonan, Korea.
Rhee, Ji-Young - Division of Infectious Diseases, Department of Medicine, Dankook University College
Wi, Yu Mi - Division of Infectious Diseases, Department of Medicine, Samsung Changwon Hospital,
Jung, Bo Kyeung - Department of Laboratory Medicine, Dankook University College of Medicine, Cheonan,
ABSTRACT
BACKGROUND: It is necessary to know the viral kinetics and conduct epidemiological investigations of confirmers to prevent the spread of the new infectious disease COVID-19 to the community. To date, no study has been published on viral kinetics during the preclinical and clinical periods of SARS-CoV-2.
METHODS: A confirmed case was defined as a patient with positive results by real-time reverse transcription polymerase chain reaction (RT-PCR) assay for SARS-CoV-2. Both specimen types were collected over the whole clinical course in all patients. Asymptomatic patients who had been screened for COVID-19 due to a strong epidemiological link were also enrolled. The study population included 54 hospitalized patients with confirmed COVID-19.
RESULTS: COVID-19 shows a very high viral load on the day of symptom development, which then decreases overall. Rapid viral proliferation was observed 0-5 days before symptoms developed. Cycle threshold (Ct) value was the lowest in the clinical course from 5 days before symptoms to 10 days after symptoms occurred (Ct < 30). The rRT-PCR results were negative approximately 3 weeks after the onset of symptoms. However, there was a continuous pattern that was negative and positive for up to 6 weeks and more. CONCLUSION: Considering the characteristic that COVID-19 has a high viral load before symptoms appear, it is necessary to consider to expand the scope of epidemiological investigations. As there is a very low possibility of transmission after 10 days of symptom occurrence, it may be considered to release isolation after 10 days of symptom occurrence in limited resource situations. This study allows for the planning of epidemiological investigations, patient's ward supply, and follow-up of patients through sequential changes in viral loads over the entire clinical course. In addition, it is possible to estimate the clinical time at which the patient is present. CI - Copyright ??2020 The Authors. Published by Elsevier Ltd.. All rights reserved.
keyword
COVID-19; SARS-CoV-2; viral load
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