Huh, Kyungmin; Lee, Rugyeom; Ji, Wonjun; Kang, Minsun; Cheol Hwang, In; Ho Lee, Dae; Jung, Jaehun
Diabetes research and clinical practice
2020Oct ; 70 ( Pt A ) :108515.
PMID : 33096185
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Huh, Kyungmin - Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Lee, Rugyeom - Artificial Intelligence and Big-Data Convergence Center, Gil Medical Center, Gachon
Ji, Wonjun - Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University
Kang, Minsun - Artificial Intelligence and Big-Data Convergence Center, Gil Medical Center, Gachon
Cheol Hwang, In - Department of Family Medicine, Gil Medical Center, Gachon University College of
Ho Lee, Dae - Department of Internal Medicine, Gil Medical Center, Gachon University College of
Jung, Jaehun - Artificial Intelligence and Big-Data Convergence Center, Gil Medical Center, Gachon
ABSTRACT
AIMS: This study aimed to assess whether body mass index (BMI), fasting plasma glucose (FPG) levels, blood pressure (BP), and kidney function were associated with the risk of severe disease or death in patients with COVID-19.
METHODS: Data on candidate risk factors were extracted from patients' last checkup records. Propensity score-matched cohorts were constructed, and logistic regression models were used to adjust for age, sex, and comorbidities. The primary outcome was death or severe COVID-19, defined as requiring supplementary oxygen or higher ventilatory support.
RESULTS: Among 7,649 patients with confirmed COVID-19, 2,231 (29.2%) received checkups and severe COVID-19 occurred in 307 patients (13.8%). A BMI of 25.0-29.9 was associated with the outcome among women (aOR, 2.29; 95% CI, 1.41-3.73) and patients aged 50-69?years (aOR, 1.64; 95% CI, 1.06-2.54). An FPG???126?mg/dL was associated with poor outcomes in women (aOR, 2.06; 95% CI, 1.13-3.77) but not in men. Similarly, estimated glomerular filtration rate (eGFR)?
CONCLUSIONS: The effects of BMI, FPG, and eGFR on outcomes associated with COVID-19 were prominent in women but not in men. CI - Copyright ??2020 Elsevier B.V. All rights reserved.
keyword
COVID-19; diabetes; dyslipidemia; hypertension; obesity; outcome
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