Shaha, Kunal Bikram; Manandhar, Dhiraj Narayan; Cho, Jung Rae; Adhikari, Ashok; K C, Man Bahadur
Postgraduate medical journal
2020Sep ; 9 ( 38 ) :.
PMID : 32943474
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Shaha, Kunal Bikram - Internal Medicine, Cardiology., Patan Academy of Health sciences, Lalitpur, Nepal drshahakunal19@gmail.com.
Manandhar, Dhiraj Narayan - Nephrology, Nepal Medical College Teaching Hospital, Kathmandu, Nepal.
Cho, Jung Rae - Cardiology, Interventional., Kangnam Sacred Heart Hospital,HUMC, Yeongdeungpo-gu,
Adhikari, Ashok - Internal Medicine, Cardiology., Patan Academy of Health sciences, Lalitpur, Nepal.
K C, Man Bahadur - Cardiology, Electrophysiology, Shahid Gangalal National Heart Centre, Kathmandu,
ABSTRACT
Since the outbreak of COVID-19 or coronavirus disease caused by severe acute respiratory syndrome coronavirus 2 from Wuhan, China, the cardiology fraternity's interest has been drawn towards the pandemic with a high case fatality rate of 10.5% and 6% in patients with heart disease and hypertension, respectively. One of the postulated mechanisms for this high fatality rate is the possible abundance of ACE type 2 receptor in the cardiovascular system that strongly binds with the spike protein of COVID-19 and helps internalise into the cell resulting in acute cardiac injury (ACI). More than 7% of cases with COVID-19 are reported to have this type of ACI. A tenfold rise in mortality has been observed in patients with COVID-19 who experience a rise in high-sensitivity (hs)-troponin. All most half of the patients who died of COVID-19 had a rise in hs-troponin. More than 15% of cases with COVID-19 experienced different types of arrhythmias. All these statistics denote how important cardiovascular pathology is in patients with COVID-19. Controversies of renin-angiotensin-aldosterone system inhibitors usage in patients with COVID-19 and meticulous handling of case with acute coronary syndrome categorically stresses cardiologists to bust the myths hovering around and set a standard guideline to counterfeit the fatality with timely diagnosis and treatment of COVID-19-induced ACI. In this review, we sought to summarise the current evidence of COVID-19-associated cardiac injury and suggest the implications for its proper diagnosis and treatment. CI - ??Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.
keyword
Angiotensin receptor blocker; Arrhythmias; COVID-19; Carditis; SARS-Cov-2
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