Arafkas, Mohamed; Khosrawipour, Tanja; Kocbach, Piotr; Zielinski, Kacper; Schubert, Justyna; Mikolajczyk, Agata; Celinska, Maria; Khosrawipour, Veria
Journal of medical virology
2021Mar ; 93 ( 3 ) :1599-1604.
PMID : 32897549
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Arafkas, Mohamed -
Khosrawipour, Tanja -
Kocbach, Piotr -
Zielinski, Kacper -
Schubert, Justyna -
Mikolajczyk, Agata -
Celinska, Maria -
Khosrawipour, Veria -
ABSTRACT
Coronavirus disease 2019 (COVID-19) reinfections could be a major aggravating factor in this current pandemic, as this would further complicate potential vaccine development and help to maintain worldwide virus pockets. To investigate this critical question, we conducted a clinical meta-analysis including all available currently reported cases of potential COVID-19 reinfections. We searched for all peer-reviewed articles in the search engine of the National Center for Biotechnology Information. While there are over 30,000 publications on COVID-19, only about 15 specifically target the subject of COVID-19 reinfections. Available patient data in these reports was analyzed for age, gender, time of reported relapse after initial infection and persistent COVID-19 positive polymerase chain reaction (PCR) results. Following the first episode of infection, cases of clinical relapse are reported at 34 (mean)?±?10.5 days after full recovery. Patients with clinical relapse have persisting positive COVID-19 PCR testing results until 39?±?9 days following initial positive testing. For patients without clinical relapse, positive testing was reported up to 54?±?24 days. There were no reports of any clinical reinfections after a 70-day period following initial infection. CI - ??2020 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC.
keyword
*COVID-19; *coronavirus; *effective; *measures; *pandemic; *spread
MESH
Adult, Aged, Aged, 80 and over, COVID-19/*diagnosis/epidemiology/pathology, Female, Humans, Male, Middle Aged, Polymerase Chain Reaction, Reinfection/*epidemiology, SARS-CoV-2, Young Adult
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