Mohapatra, Ranjan K; Pintilie, Lucia; Kandi, Venkataramana; Sarangi, Ashish K; Das, Debadutta; Sahu, Raghaba; Perekhoda, Lina
Chemical biology & drug design
2020Nov ; 96 ( 5 ) :1187-1208.
PMID : 32654267
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Mohapatra, Ranjan K - Department of Chemistry, Government College of Engineering, Keonjhar, Odisha, India.
Pintilie, Lucia - Department of Synthesis of Bioactive Substances and Pharmaceutical Technologies,
Kandi, Venkataramana - Department of Microbiology, Pratima Institute of Medical Sciences, Karimnagar,
Sarangi, Ashish K - Department of Chemistry, School of Applied Sciences, Centurion University of
Das, Debadutta - Department of Chemistry, Sukanti Degree College, Subarnapur, Odisha, India.
Sahu, Raghaba - College of Pharmacy, Seoul National University, Seoul, South Korea.
Perekhoda, Lina - Department of medicinal chemistry, National University of Pharmacy, Kharkiv,
ABSTRACT
COVID-19 is highly contagious pathogenic viral infection initiated from Wuhan seafood wholesale market of China on December 2019 and spread rapidly around the whole world due to onward transmission. This recent outbreak of novel coronavirus (CoV) was believed to be originated from bats and causing respiratory infections such as common cold, dry cough, fever, headache, dyspnea, pneumonia, and finally Severe Acute Respiratory Syndrome (SARS) in humans. For this widespread zoonotic virus, human-to-human transmission has resulted in nearly 83 lakh cases in 213 countries and territories with 4,50,686 deaths as on 19 June 2020. This review presents a report on the origin, transmission, symptoms, diagnosis, possible vaccines, animal models, and immunotherapy for this novel virus and will provide ample references for the researchers toward the ongoing development of therapeutic agents and vaccines and also preventing the spread of this disease. CI - ??2020 John Wiley & Sons A/S.
keyword
*COVID-19 pneumonia; *animal models and immunotherapy; *diagnosis; *entry mechanism; *possible vaccines; *symptoms; *transmission
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