Jung, Sun-Young; Choi, Jae Chol; You, Seung-Hun; Kim, Won-Young
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2020Nov ; 71 ( 16 ) :2121-2128.
PMID : 32442285
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Jung, Sun-Young - College of Pharmacy, Chung-Ang University, Seoul, Republic of Korea.
Choi, Jae Chol - Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University
You, Seung-Hun - College of Pharmacy, Chung-Ang University, Seoul, Republic of Korea.
Kim, Won-Young - Department of Internal Medicine, Chung-Ang University Hospital, Chung-Ang University
ABSTRACT
BACKGROUND: Renin-angiotensin-aldosterone system (RAAS) inhibitors may facilitate host cell entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or attenuate organ injury via RAAS blockade. We aimed to assess the associations between prior use of RAAS inhibitors and clinical outcomes among Korean patients with coronavirus disease 2019 (COVID-19).
METHODS: We performed a nationwide population-based cohort study using the Korean Health Insurance Review and Assessment database. Claim records were screened for 69 793 individuals who were tested for COVID-19 until 8 April 2020. Adjusted odds ratios (ORs) were used to compare the clinical outcomes between RAAS inhibitor users and nonusers.
RESULTS: Among 5179 confirmed COVID-19 cases, 762 patients were RAAS inhibitor users and 4417 patients were nonusers. Relative to nonusers, RAAS inhibitor users were more likely to be older, male, and have comorbidities. Among 1954 hospitalized patients with COVID-19, 377 patients were RAAS inhibitor users, and 1577 patients were nonusers. In-hospital mortality was observed for 33 RAAS inhibitor users (9%) and 51 nonusers (3%) (P?
CONCLUSIONS: Our findings suggest that prior use of RAAS inhibitors was not independently associated with mortality among COVID-19 patients in Korea. CI - ??The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.
keyword
*ACEI/ARB; *COVID-19; *SARS-CoV-2; *comorbidity; *renin-angiotensin system
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