Baek, Hee Sun; Kim, Seong Heon; Kang, Hee Gyung; Choi, Hyun Jin; Cheong, Hae Il; Ha, Il Soo; Han, Kyoung Hee; Cho, Hee Yeon; Shin, Jae Il; Park, Young Seo; Lee, Joo Hoon; Ahn, Yo Han; Park, Eujin; Cho, Min Hyun
Pediatric nephrology (Berlin, Germany)
2020Mar ; 12 ( 4 ) :.
PMID : 32232640
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Baek, Hee Sun - Department of Pediatrics, Kyungpook National University, School of Medicine, 130 Dongdeok-ro, Jung-gu, Daegu, 41944, Republic of Korea.
Kim, Seong Heon - Department of Pediatrics, Pusan National University Children's Hospital, Yangsan,
Kang, Hee Gyung - Department of Pediatrics, Seoul National University Children's Hospital, Seoul,
Choi, Hyun Jin - Department of Pediatrics, Seoul National University Children's Hospital, Seoul,
Cheong, Hae Il - Department of Pediatrics, Seoul National University Children's Hospital, Seoul,
Ha, Il Soo - Department of Pediatrics, Seoul National University Children's Hospital, Seoul,
Han, Kyoung Hee - Department of Pediatrics, Jeju University Hospital, Jeju, Republic of Korea.
Cho, Hee Yeon - Department of Pediatrics, Samsung Medical Center, Seoul, Republic of Korea.
Shin, Jae Il - Department of Pediatrics, Severance Children's Hospital, Seoul, Republic of
Park, Young Seo - Department of Pediatrics, Asan Medical Center, Seoul, Republic of Korea.
Lee, Joo Hoon - Department of Pediatrics, Asan Medical Center, Seoul, Republic of Korea.
Ahn, Yo Han - Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam,
Park, Eujin - Department of Pediatrics, Hallym University Kangnam Sacred Heart Hospital, Seoul,
Cho, Min Hyun - Department of Pediatrics, Kyungpook National University, School of Medicine, 130
ABSTRACT
BACKGROUND: Pediatric as well as adult patients with chronic kidney disease (CKD) are susceptible to cardiovascular disease (CVD) events, which increase their mortality. Dyslipidemia is thought to be one of the most important contributing risk factors for developing CVD. This study aimed to evaluate the prevalence of dyslipidemia and assess clinical and laboratory risk factors associated with dyslipidemia in East Asian pediatric patients with CKD.
METHODS: From April 2011 to April 2016, 469 patients with CKD aged
RESULTS: The prevalence of dyslipidemia was 61.5% (n?=?219). For dyslipidemia, nephrotic range proteinuria and 25-hydroxyvitamin D deficiency significantly increased the adjusted odds ratio. In the subanalysis, glomerulonephropathy as the origin of CKD and nephrotic range proteinuria significantly increased the risks for high total cholesterol and high low-density lipoprotein cholesterol. Overweight or obese body mass index z-score, elevated proteinuria, hypocalcemia, and 1,25-dihydroxyvitamin D deficiency were significantly associated with low high-density lipoprotein cholesterol. Glomerular filtration rate stage 3b or higher and hyperphosphatemia significantly increased the risk for high triglycerides.
CONCLUSIONS: Long-term data accumulation and prospective analysis are needed to clarify the relationship between CKD progression and dyslipidemia and to find additional risk factors for dyslipidemia.
keyword
Cardiovascular disease; Children; Cholesterol; Chronic kidney disease; Cohort; Dyslipidemia; Triglycerides
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