Bhattacharya, Manojit; Sharma, Ashish R; Patra, Prasanta; Ghosh, Pratik; Sharma, Garima; Patra, Bidhan C; Lee, Sang-Soo; Chakraborty, Chiranjib
Journal of medical virology
2020Feb ; 570 ( 3 ) :.
PMID : 32108359
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Bhattacharya, Manojit -
Sharma, Ashish R -
Patra, Prasanta -
Ghosh, Pratik -
Sharma, Garima -
Patra, Bidhan C -
Lee, Sang-Soo -
Chakraborty, Chiranjib -
ABSTRACT
Recently, a novel coronavirus (SARS-COV-2) emerged which is responsible for the recent outbreak in Wuhan, China. Genetically, it is closely related to SARS-CoV and MERS-CoV. The situation is getting worse and worse, therefore, there is an urgent need for designing a suitable peptide vaccine component against the SARS-COV-2. Here, we characterized spike glycoprotein to obtain immunogenic epitopes. Next, we chose 13 Major Histocompatibility Complex-(MHC) I and 3 MHC-II epitopes, having antigenic properties. These epitopes are usually linked to specific linkers to build vaccine components and molecularly dock on toll-like receptor-5 to get binding affinity. Therefore, to provide a fast immunogenic profile of these epitopes, we performed immunoinformatics analysis so that the rapid development of the vaccine might bring this disastrous situation to the end earlier. CI - ??2020 Wiley Periodicals, Inc.
keyword
SARS-COV-2;epitopes;immunoinformatics;vaccine
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