Hwang, In-Chang; Kim, Hyung-Kwan; Park, Jun-Bean; Park, Eun-Ah; Lee, Whal; Lee, Seung-Pyo; Kim, Yong-Jin; Sohn, Dae-Won; Oh, Jae K
European heart journal cardiovascular Imaging
2019Aug ; 8 ( 8 ) :.
PMID : 31377777
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Hwang, In-Chang -
Kim, Hyung-Kwan -
Park, Jun-Bean -
Park, Eun-Ah -
Lee, Whal -
Lee, Seung-Pyo -
Kim, Yong-Jin -
Sohn, Dae-Won -
Oh, Jae K -
ABSTRACT
AIMS: Native T1 times from T1 mapping cardiac magnetic resonance (CMR) are associated with myocardial fibrosis in aortic stenosis (AS). We investigated whether changing patterns in native T1 predict clinical outcomes after aortic valve replacement (AVR) in severe AS patients. METHODS AND
RESULTS: Forty-three patients with severe AS (65.9?±?8.1?years; 24 men) who underwent T1 mapping CMR at baseline and 1?year after AVR were prospectively enrolled. Upper limit of native T1 from healthy volunteers was used to define normal myocardium and diffuse fibrosis (native T1?1208.4 and ??208.4?ms, respectively). Participants were categorized into Group 1 (pre- and post-AVR normal myocardium; n?=?11), Group 2 (pre-AVR diffuse fibrosis and post-AVR normal myocardium; n?=?18), and Group 3 (post-AVR diffuse fibrosis; n?=?14). Native T1 significantly decreased 1?year after AVR (pre-AVR, 1233.8?±?49.7?ms; post-AVR, 1189.1?±?58.4?ms; P?0.001), which was associated with left ventricular (LV) mass regression (?³native T1 vs. ?³LV mass index, r?=?0.454, P?=?0.010) and systolic function improvement (?³native T1 vs. ?³LV ejection fraction, r?=?-0.379, P?=?0.012). Group 2 showed greater functional improvements, whereas these benefits were blunted in Group 3. Group 3 had significantly worse outcomes than Group 1 [hazard ratio (HR), 9.479, 95% confidence interval (CI) 1.176-76.409; P?=?0.035] and Group 2 (HR 3.551, 95% CI 1.178-10.704; P?=?0.024). CONCLUSION: AVR-induced changes in native T1 values are associated with LV systolic functional changes as well as prognosis in severe AS. Post-AVR T1 mapping CMR can be used as an imaging biomarker. CI - Published on behalf of the European Society of Cardiology. All rights reserved. ??The Author(s) 2019. For permissions, please email: journals.permissions@oup.com.
keyword
aortic stenosis;aortic valve replacement;cardiac magnetic resonance;myocardial fibrosis;native T1
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