Aortic valve replacement-induced changes in native T1 are related to prognosis in severe aortic stenosis: T1 mapping cardiac magnetic resonance imaging study.

Hwang, In-Chang; Kim, Hyung-Kwan; Park, Jun-Bean; Park, Eun-Ah; Lee, Whal; Lee, Seung-Pyo; Kim, Yong-Jin; Sohn, Dae-Won; Oh, Jae K
European heart journal cardiovascular Imaging
2019Aug ; 8 ( 8 ) :.
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Hwang, In-Chang -
Kim, Hyung-Kwan -
Park, Jun-Bean -
Park, Eun-Ah -
Lee, Whal -
Lee, Seung-Pyo -
Kim, Yong-Jin -
Sohn, Dae-Won -
Oh, Jae K -
ABSTRACT
AIMS: Native T1 times from T1 mapping cardiac magnetic resonance (CMR) are associated with myocardial fibrosis in aortic stenosis (AS). We investigated whether changing patterns in native T1 predict clinical outcomes after aortic valve replacement (AVR) in severe AS patients. METHODS AND

RESULTS: Forty-three patients with severe AS (65.9?±?8.1?years; 24 men) who underwent T1 mapping CMR at baseline and 1?year after AVR were prospectively enrolled. Upper limit of native T1 from healthy volunteers was used to define normal myocardium and diffuse fibrosis (native T1?
keyword
aortic stenosis;aortic valve replacement;cardiac magnetic resonance;myocardial fibrosis;native T1
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The changes in native T1 values after AVR showed significant associations with changes in LV-EF (r = −0.379; P = 0.012), LV-EDVi (r = 0.345; P = 0.023), and LV-MI (r = 0.454; P = 0.010); AVR-induced changes in native T1 values are associated with LV systolic functional changes as well as prognosis in severe AS.
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DOI
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ICD 03
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