Value of blood oxygenation level-dependent MRI for predicting clinical outcomes in uterine cervical cancer treated with concurrent chemoradiotherapy.

Lee, Jiyeong; Kim, Chan Kyo; Gu, Kyo-Won; Park, Won
European radiology
2019Apr ; 51 ( 8 ) :.
PMID : 31016443
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Lee, Jiyeong -
Kim, Chan Kyo -
Gu, Kyo-Won -
Park, Won -
ABSTRACT
OBJECTIVES: To investigate the value of blood oxygenation level-dependent (BOLD) MRI as a predictor of clinical outcomes in cervical cancer patients treated with concurrent chemoradiotherapy (CCRT). METHOD: Enrolled 92 patients with stage IB2-IVB cervical cancer who received CCRT underwent 3-T BOLD MRI before treatment. The R2* value (rate of spin dephasing, s(-1)) was measured in the tumor. Cox regression analysis was used to evaluate the associations of imaging and clinical parameters with progression-free survival (PFS) and cancer-specific survival (CSS). Inter-reader reliability for the R2* measurements was evaluated using an intraclass correlation coefficient (ICC).

RESULTS: Tumor R2* values were significantly different between patients with and without disease progression (p?
keyword
Cervical cancer; Hypoxia; Magnetic resonance imaging; Radiotherapy; Treatment outcome
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Pretreatment BOLD MRI as a prognostic marker may be useful for predicting clinical outcome in patients with cervical cancer treated with CCRT, with good inter-reader reliability.
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DOI
10.1007/s00330-019-06198-5
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ICD 03
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