Value of blood oxygenation level-dependent MRI for predicting clinical outcomes in uterine cervical cancer treated with concurrent chemoradiotherapy.

Lee, Jiyeong; Kim, Chan Kyo; Gu, Kyo-Won; Park, Won
European radiology
2019Apr ; 51 ( 8 ) :.
저자 상세정보
Lee, Jiyeong -
Kim, Chan Kyo -
Gu, Kyo-Won -
Park, Won -
ABSTRACT
OBJECTIVES: To investigate the value of blood oxygenation level-dependent (BOLD) MRI as a predictor of clinical outcomes in cervical cancer patients treated with concurrent chemoradiotherapy (CCRT). METHOD: Enrolled 92 patients with stage IB2-IVB cervical cancer who received CCRT underwent 3-T BOLD MRI before treatment. The R2* value (rate of spin dephasing, s(-1)) was measured in the tumor. Cox regression analysis was used to evaluate the associations of imaging and clinical parameters with progression-free survival (PFS) and cancer-specific survival (CSS). Inter-reader reliability for the R2* measurements was evaluated using an intraclass correlation coefficient (ICC).

RESULTS: Tumor R2* values were significantly different between patients with and without disease progression (p?
keyword
Cervical cancer; Hypoxia; Magnetic resonance imaging; Radiotherapy; Treatment outcome
링크

주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
Pretreatment BOLD MRI as a prognostic marker may be useful for predicting clinical outcome in patients with cervical cancer treated with CCRT, with good inter-reader reliability.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
DOI
10.1007/s00330-019-06198-5
KCD코드
ICD 03
건강보험코드