KCTBASE

Harnessing immune checkpoints in myeloid lineage cells for cancer immunotherapy.

Park, Seung-Yoon; Kim, In-San

Cancer letters
2019Mar ; 452 ( 1 ) :51-58.

PMID : 30910590

저자 상세정보

Park, Seung-Yoon -
Kim, In-San -

ABSTRACT

Myeloid lineage immune cells, such as macrophages and dendritic cells, play important roles in the induction of antitumor immunity during the initial stage of the cancer-immunity cycle, eliciting antitumor adaptive immunity by phagocytosing cancer cells and processing cancer-specific antigens, and then presenting these antigens to T cells. During this process, cancer cell phagocytosis can be prevented by inhibitory signals, and the signaling cascades that elicit immune responses against cancer antigens can be inhibited by immunosuppressive myeloid cells in the tumor microenvironment. A number of therapeutic strategies for enhancing cancer cell phagocytosis and promoting antitumor immunity by targeting myeloid lineage cells have recently been developed. Here, we discuss recent advances in cancer immunotherapy that involve the targeting of myeloid lineage immune cells to induce effective antitumor immunity. CI - Copyright ??2019 Elsevier B.V. All rights reserved.

keyword

Antitumer immunity; Dendritic cells; Macrophages; Phagocytosis

링크

PubMed

주제코드

주제명(Target field)

연구대상(Population)

연구참여(Sample size)

대상성별(Gender)

질병특성(Condition Category)

연구환경(Setting)

연구설계(Study Design)

연구기간(Period)

중재방법(Intervention Type)

중재명칭(Intervention Name)

키워드(Keyword)

유효성결과(Recomendation)

Myeloid lineage immune cells are important for the induction of antitumor immunity ; This article discussed recent advances in cancer immunotherapy that involve the targeting of myeloid lineage immune cells to induce effective antitumor immunity.

연구비지원(Fund Source)

근거수준평가(Evidence Hierarchy)

출판년도(Year)

참여저자수(Authors)

대표저자

DOI

10.1016/j.canlet.2019.03.018

KCD코드

ICD 03

건강보험코드