Comparison of efficacy and complications between radiofrequency ablation and repeat surgery in the treatment of locally recurrent thyroid cancers: a single-center propensity score matching study.

Choi, Yangsean; Jung, So Lyung; Bae, Ja-Sung; Lee, So-Hee; Jung, Chan-Kwon; Jang, Jinhee; Shin, Na-Young; Choi, Hyun Seok; Ahn, Kook-Jin; Kim, Bum-Soo
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
2019Mar ; 16 ( 5 ) :1-9.
저자 상세정보
Choi, Yangsean - a Department of Radiology , The Catholic University of Korea College of Medicine, Seoul St. Mary's Hospital , Seoul , Korea.
Jung, So Lyung - a Department of Radiology , The Catholic University of Korea College of Medicine, Seoul St. Mary's Hospital , Seoul , Korea.
Bae, Ja-Sung - b Department of Thyroid Surgery , The Catholic University of Korea College of Medicine, Seoul St. Mary's Hospital , Seoul , Korea.
Lee, So-Hee - b Department of Thyroid Surgery , The Catholic University of Korea College of Medicine, Seoul St. Mary's Hospital , Seoul , Korea.
Jung, Chan-Kwon - c Department of Pathology , The Catholic University of Korea College of Medicine, Seoul St. Mary's Hospital , Seoul , Korea.
Jang, Jinhee - a Department of Radiology , The Catholic University of Korea College of Medicine, Seoul St. Mary's Hospital , Seoul , Korea.
Shin, Na-Young - a Department of Radiology , The Catholic University of Korea College of Medicine, Seoul St. Mary's Hospital , Seoul , Korea.
Choi, Hyun Seok - a Department of Radiology , The Catholic University of Korea College of Medicine, Seoul St. Mary's Hospital , Seoul , Korea.
Ahn, Kook-Jin - a Department of Radiology , The Catholic University of Korea College of Medicine, Seoul St. Mary's Hospital , Seoul , Korea.
Kim, Bum-Soo - a Department of Radiology , The Catholic University of Korea College of Medicine, Seoul St. Mary's Hospital , Seoul , Korea.
ABSTRACT
PURPOSE: To compare the efficacy and complication rates of radiofrequency ablation (RFA) and repeat surgery in the treatment of locally recurrent thyroid cancers. MATERIALS AND

METHODS: A total of 221 patients with locally recurrent thyroid cancers who underwent either RFA (n?=?96) or repeat surgery (n?=?125) between March 2008 and March 2017 were retrospectively enrolled (range of follow-up, 1-10?years). Each cohort consisted of 70 patients after propensity score adjustment. Patients with more than three recurrent lesions were excluded. The primary and secondary end points were recurrence-free survival and complication rates, respectively. Recurrence-free survival curves were compared via the log-rank test. The complications-voice changes, hypocalcemia, and immediate procedural complications-were compared between the groups. In addition, pretreatment serum thyroglobulin (T(g)) levels and those at the last follow-up were also compared between the two groups to examine therapeutic efficacy.

RESULTS: After propensity score matching, both groups showed no significant differences in baseline characteristics. The recurrence-free survival rates were comparable between the RFA and surgery groups (p?=?.2). There were no significant differences in mean serum T(g) levels and their mean decrease after treatment between the groups (p?=?.891 and p?=?.963, respectively). Immediate procedural complications and voice changes also showed no significant between-group differences (p?=?.316, p?=?.084, respectively). Hypocalcemia occurred only in the repeat surgery group (n?=?18). Overall complications were significantly more frequent in the repeat surgery group (RFA, n?=?7; surgery, n?=?27; p?
keyword
Thyroid; radiofrequency ablation; recurrent thyroid cancer; thermal ablation; ultrasound
링크

주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
In conclusion, the effectiveness of RFA for controlling locally recurrent thyroid cancers was similar to that of repeat surgery, with RFA resulting in fewer overall complications. ; RFA may be an effective and safe alternative to repeat surgery in the treatment of a small number of locally recurrent thyroid cancers.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
DOI
10.1080/02656736.2019.1571248
KCD코드
ICD 03
건강보험코드