Diagnostic performance of F-18 FDG PET/CT for prediction of KRAS mutation in colorectal cancer patients: a systematic review and meta-analysis.

Kim, Seong-Jang; Pak, Kyoungjune; Kim, Keunyoung
Abdominal radiology (New York)
2019Jan ; 20 ( 1 ) :.
저자 상세정보
Kim, Seong-Jang -
Pak, Kyoungjune -
Kim, Keunyoung -
ABSTRACT
OBJECTIVE: The purpose of the current study was to investigate the diagnostic performance of F-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for the prediction of v-Ki-ras-2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation in colorectal cancer (CRC) patients through a systematic review and meta-analysis.

METHODS: The PubMed and EMBASE database, from the earliest available date of indexing through April 30, 2018, were searched for studies evaluating the diagnostic performance of F-18 FDG PET/CT for prediction of KRAS mutation in CRC patients.

RESULTS: Across 9 studies (804 patients), the pooled sensitivity for F-18 FDG PET/CT was 0.66 (95% CI 0.60-0.73) without heterogeneity (I(2)?=?34.1, p?=?0.14) and a pooled specificity of 0.67 (95% CI 0.62-0.72) without heterogeneity (I(2)?=?1.63, p?=?0.42). Likelihood ratio (LR) syntheses gave an overall positive likelihood ratio (LR+) of 2.0 (95% CI 1.7-2.4) and negative likelihood ratio (LR-) of 0.5 (95% CI 0.41-0.61). The pooled diagnostic odds ratio (DOR) was 4 (95% CI 3-6). Hierarchical summary receiver operating characteristic (ROC) curve indicates that the areas under the curve were 0.69 (95% CI 0.65-0.73). CONCLUSION: The current meta-analysis showed the low sensitivity and specificity of F-18 FDG PET/CT for prediction of KRAS mutation in CRC patients. The DOR was very low and the likelihood ratio scatter-gram indicated that F-18 FDG PET/CT might not be useful for prediction of KRAS mutation and not for its exclusion. Therefore, cautious application and interpretation should be paid to the F-18 FDG PET/CT for prediction of KRAS mutation in CRC patients.
keyword
Colon cancer; F-18 FDG; KRAS; PET/CT; Rectal cancer
링크

주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
F-18 FDG PET/CT might not be useful for the prediction of KRAS mutation in CRC patients and cautious application and interpretation should be paid to the F-18 FDG PET/CT for the prediction of KRAS mutation in CRC patients.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
DOI
KCD코드
ICD 03
건강보험코드