Successful radiofrequency ablation strategies for benign thyroid nodules.

Lee, Gee Mun; You, Ji Young; Kim, Hoon Yub; Chai, Young Jun; Kim, Hong Kyu; Dionigi, Gianlorenzo; Tufano, Ralph P
Endocrine
2018Dec ; 170 ( 12 ) :.
저자 상세정보
Lee, Gee Mun - Kangbuk Seoul Surgery, Seoul, Korea.
You, Ji Young - Department of Surgery, KUMC Thyroid Center, Korea University Hospital, Korea University College of Medicine, Seoul, Korea.
Kim, Hoon Yub - Department of Surgery, KUMC Thyroid Center, Korea University Hospital, Korea University College of Medicine, Seoul, Korea. hoonyubkim@korea.ac.kr.
Chai, Young Jun - Department of Surgery, Seoul Metropolitan Government - Seoul National University Boramae Medical Center, Seoul, Korea.
Kim, Hong Kyu - Department of Surgery, KUMC Thyroid Center, Korea University Hospital, Korea University College of Medicine, Seoul, Korea.
Dionigi, Gianlorenzo - Division for Endocrine and Minimal Invasive Surgery, Department of Human Pathology in Adulthood and Childhood "G. Barresi', University Hospital "G. Martino", University of Messina, Messina, Italy.
Tufano, Ralph P - Department of Otolaryngology - Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
ABSTRACT
PURPOSE: This study aimed to evaluate the effectiveness of ultrasound (US)-guided radiofrequency ablation (RFA) treatment of benign thyroid nodules in consecutive large number series. To find out whether there is any difference according to the nature of the nodules, nodules were subdivided into two groups of predominantly solid vs. predominantly cystic lesions.

METHODS: We retrospectively analyzed clinical data of thyroid nodules receiving percutaneous RFA treatment in our institution. We subdivided data into two groups according to the nodule's sonographic characteristics. We defined therapeutic success as a volume reduction rate >50% at 6 months post-RFA. The second ablation was performed in case where <50% VRR was achieved at 6 months. The primary endpoint was to identify factors prognosticating response to RFA treatment.

RESULTS: A total of 1000 patients with 1619 thyroid nodules received US-guided RFA treatment. A volume reduction of >50% (therapeutic success) after the first ablation was 78.9% vs. 78.2% (p?=?0.439) and 91.4% vs. 93.4% (p?=?0.148) after the final ablation for predominantly cystic vs. predominantly solid lesions, respectively, with comparable post-interventional morbidity. RFA sessions were more frequent in the solid group than in the cystic group. Small volume of thyroid nodule (<4?mL) was the only factor significantly associated with therapeutic success in the multivariate analysis (OR 1.848; 95% CI 1.537-2.789, p?=?0.030). CONCLUSION: RFA was effective in reducing the volume of benign thyroid nodules volume with non-inferior result in PS group comparing to PC group and can be considered a principal treatment method for treating benign thyroid nodules, including cystic nodules.
keyword
Benign thyroid nodule; Nature of thyroid nodule; Radiofrequency ablation; Therapeutic success; Volume reduction
링크

주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
A volume reduction of >50% (therapeutic success) after the first ablation was 78.9% vs. 78.2% (p = 0.439) and 91.4% vs. 93.4% (p = 0.148); RFA can be considered a principal treatment method for treating benign thyroid nodules, including cystic nodules.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
DOI
10.1007/s12020-018-1829-4
KCD코드
ICD 03
건강보험코드