Shukla, Malay; Park, Jae-Hyeong; Thomas, James D; Delgado, Victoria; Bax, Jeroen J; Kane, Garvan C; Howlett, Jonathan G; White, James A; Fine, Nowell M
The Canadian journal of cardiology
2018Aug ; 34 ( 8 ) :1069-1078.
PMID : 30056845
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Shukla, Malay - Division of Cardiology, Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Park, Jae-Hyeong - Cardiology Division of Internal Medicine, Chungnam National University, Chungnam National University Hospital, Daejeon, Korea.
Thomas, James D - Centre for Heart Valve Disease, Bluhm Cardiovascular Institute, Northwestern Memorial Hospital, Chicago, Illinois, USA.
Delgado, Victoria - Department of Cardiology, Leiden University Medical Centre, Leiden, the Netherlands.
Bax, Jeroen J - Department of Cardiology, Leiden University Medical Centre, Leiden, the Netherlands.
Kane, Garvan C - Division of Cardiovascular Ultrasound, Department of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota, USA.
Howlett, Jonathan G - Division of Cardiology, Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
White, James A - Division of Cardiology, Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Fine, Nowell M - Division of Cardiology, Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address nmfine@ucalgary.ca.
ABSTRACT
BACKGROUND: Right ventricular (RV) strain imaging using speckle-tracking echocardiography (STE) is a quantitative method of assessing RV systolic function that has shown prognostic utility in patients with pulmonary hypertension (PH). However, its prognostic value for a large and mixed PH population remains poorly defined.
METHODS: A systematic review and meta-analysis was performed using the MedLine, Embase, and Cochrane Library databases for publications reporting the prognostic value of RV strain calculated using 2-dimensional STE in PH patients for the clinical end point of all-cause mortality.
RESULTS: Screening of 687 publications yielded 10 that were included in the meta-analysis, representing data for 1001 PH patients, among whom 76% had pulmonary arterial hypertension with the remainder having a range of PH etiologies. The pooled free wall RV strain was?-16.2% (95% confidence interval [CI],?-14.3 to?-18.1; I(2)?= 94.1%; Q?= 102.8; P < 0.001), and the global (free wall and septum) RV strain was?-14.5% (95% CI,?-12.9 to?-16; I(2)?= 84.9%; Q?= 20; P?
CONCLUSIONS: RV strain performed using 2-dimensional STE provides important prognostic value within a large and mixed population of PH patients. CI - Copyright ??2018 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.
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