Rajendrakumar, Santhosh Kalash; Uthaman, Saji; Cho, Chong-Su; Park, In-Kyu
Biomacromolecules
2018Jun ; 19 ( 6 ) :1869-1887.
PMID : 29677439
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Rajendrakumar, Santhosh Kalash - Department of Biomedical Science and BK21 PLUS Center for Creative Biomedical Scientists at Chonnam National University , Chonnam National University Medical School , Gwangju 61469 , South Korea.
Uthaman, Saji - Department of Polymer Science and Engineering , Chungnam National University , 99 Daehak-ro , Yuseong-gu, Daejeon 34134 , South Korea.
Cho, Chong-Su - Department of Agricultural Biotechnology and Research Institute for Agriculture and Life Sciences , Seoul National University , Seoul 08826 , South Korea.
Park, In-Kyu - Department of Biomedical Science and BK21 PLUS Center for Creative Biomedical Scientists at Chonnam National University , Chonnam National University Medical School , Gwangju 61469 , South Korea.
ABSTRACT
Immune system evasion by cancer cells is one of the hallmarks of cancers, and it occurs with the support of tumor-associated immune cells (TICs) in the tumor microenvironment that increase the growth and invasiveness of tumor cells. With recent advancements in the development of novel near-infrared (NIR)-responsive nanoparticles, specifically eradicating TICs or inducing an inflammatory immune response by activating killer T cells has become possible. This review will discuss the mechanisms and applications of phototriggered immunotherapy in detail. In addition, various nanoparticles employed in phototriggered immunotherapy for cancer treatment will be covered. Furthermore, the challenges and future directions of phototriggered nanoparticle development for anticancer immunotherapy will be briefly discussed.
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