Radiofrequency ablation for treatment of locally recurrent thyroid cancer presenting as a metastatic lymph node with dense macrocalcification: A case report and literature review.

Yoo, Roh-Eul; Kim, Ji-Hoon; Paeng, Jin Chul; Park, Young Joo
Medicine
2018Mar ; 97 ( 9 ) :e0003.
저자 상세정보
Yoo, Roh-Eul - Department of Radiology, Seoul National University College of Medicine, Seoul, Korea.
Kim, Ji-Hoon - Department of Radiology, Seoul National University College of Medicine, Seoul, Korea.
Paeng, Jin Chul - Department of Nuclear Medicine.
Park, Young Joo - Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
ABSTRACT
RATIONALE: Long-term recurrence rate of differentiated thyroid carcinoma has been reported to be as high as 30%. Repeat surgery may be challenging due to normal tissue plane distortion secondary to postoperative fibrosis, especially for small-sized recurrences. Recently, radiofrequency ablation (RFA) has been suggested to be a safe and effective alternative for high-risk patients or those who refuse surgery. Nonetheless, the efficacy of RFA remains questionable for densely calcified lymph nodes, which would have an increased likelihood of leaving residues after RFA. PATIENT CONCERNS: We present a case of a successful combined treatment of a metastatic lymph node with dense macrocalcification with the use of a single RFA session and radioactive iodine (RAI) ablation in a patient with a previous history of total thyroidectomy and neck node dissection for papillary thyroid carcinoma. DIAGNOSES: A 71-year-old man with papillary thyroid carcinoma underwent total thyroidectomy and neck node dissection followed by RAI ablation. The stimulated serum thyroglobulin level was 4.74?ng/mL at the time of RAI ablation, and the follow-up ultrasonography 3 months later revealed a 15-mm lymph node with dense macrocalcification at the right cervical level III. INTERVENTIONS: After confirming metastasis on cytology, the lesion was treated with ultrasound-guided RFA. OUTCOMES: The single RFA session combined with RAI ablation led to biochemical remission at 5 months after RFA, and complete resolution of structural recurrence including macrocalcification was observed 7 months after the second RAI (1 year after RFA). The patient remained free of recurrence at the 5-year follow-up. LESSONS: RFA may offer a safe and effective alternative to 'berry picking' surgery in cases of surgical ineligibility or patient refusal of surgery even when the target lesions contain dense macrocalcification.
dense macrocalcification, lymph node, papillary thyroid carcinoma, radioactive iodine, radiofrequency ablation
MESH
Aged, Calcinosis/pathology, Carcinoma, Papillary/diagnostic imaging/*pathology/*surgery, *Catheter Ablation, Humans, Iodine Radioisotopes/therapeutic use, Lymph Nodes/diagnostic imaging/pathology, Lymphatic Metastasis, Male, Neoplasm Recurrence, Local/diagnostic imaging/*pathology/*surgery, Retrospective Studies, Thyroid Neoplasms/diagnostic imaging/*pathology/*surgery, Thyroidectomy, Ultrasonography
링크

주제코드
주제명(Target field)
연구대상(Population)
연구참여(Sample size)
대상성별(Gender)
질병특성(Condition Category)
연구환경(Setting)
연구설계(Study Design)
연구기간(Period)
중재방법(Intervention Type)
중재명칭(Intervention Name)
키워드(Keyword)
유효성결과(Recomendation)
This article presented a case of recurrent papillary thyroid carcinoma manifesting as a metastatic lymph node with dense macrocalcification in which a single RFA session combined with RAI ablation led to complete resolution (in terms of both imaging and biochemical findings) and no recurrence at the 5-year follow-up.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
출판년도(Year)
참여저자수(Authors)
대표저자
DOI
10.1097/MD.0000000000010003
KCD코드
ICD 03
건강보험코드