Impact of peripheral artery disease on early and late outcomes of transcatheter aortic valve implantation in patients with severe aortic valve stenosis.

Kim, Byung Gyu; Ko, Young-Guk; Hong, Sung-Jin; Ahn, Chul-Min; Kim, Jung-Sun; Kim, Byeong-Keuk; Choi, Donghoon; Jang, Yangsoo; Hong, Myeong-Ki; Lee, Seung Hyun; Lee, Sak; Chang, Byung-Chul
International journal of cardiology
2018Mar ; 255 ( 4 ) :206-211.
저자 상세정보
Kim, Byung Gyu -
Ko, Young-Guk -
Hong, Sung-Jin -
Ahn, Chul-Min -
Kim, Jung-Sun -
Kim, Byeong-Keuk -
Choi, Donghoon -
Jang, Yangsoo -
Hong, Myeong-Ki -
Lee, Seung Hyun -
Lee, Sak -
Chang, Byung-Chul -
AIMS: Peripheral artery disease (PAD) is frequently present in patients undergoing transcatheter aortic valve implantation (TAVI) for severe aortic stenosis. This study assessed the impact of PAD on clinical outcome after TAVI.

METHODS: A total of 115 patients who underwent TAVI were evaluated retrospectively. Patients were divided into PAD and non-PAD groups, with PAD defined as stenosis??0% in lower extremity arteries. Immediate and late clinical outcomes were compared between the two groups.

RESULTS: PAD was present in 31.3% (36/115) of the patients undergoing TAVI. Compared to the non-PAD group, the PAD group had higher Society of Thoracic Surgeons' (STS) risk scores (8.83%짹6.20% vs 6.23%짹4.15%, p=0.039) and more frequent diagnoses of diabetes (52.8% vs 30.4%, p=0.021) and multi-vessel coronary artery disease (55.6% vs 29.1%, p=0.007). The PAD group also had higher incidence of major vascular complication (11.1% vs 1.3%, p=0.033), 30-day mortality (13.9% vs 1.3%, p<0.001), and subsequent 1-year (30.6% vs 3.8%, p<0.001) and 2-year (47.2% vs. 10.1%, p<0.001) all-cause mortality. PAD was identified as an independent predictor of increased 1-year mortality (hazard ratio [HR] 8.65; 95% confidence interval [CI], 1.05-71.14, p=0.045) after TAVI along with high STS score (HR 11.18, 95% CI 1.36-92.04, p=0.025).

CONCLUSIONS: Presence of PAD was significantly associated with increased rates of major vascular complications as well as immediate and late mortality in patients undergoing TAVI. Assessment of PAD before TAVI is essential to choose an access strategy and to predict clinical results. CI - Copyright ??2017 Elsevier Ireland Ltd. All rights reserved.
Aortic stenosis; Clinical outcome; Peripheral artery disease; Transcatheter aortic valve implantation

주제명(Target field)
연구참여(Sample size)
질병특성(Condition Category)
연구설계(Study Design)
중재방법(Intervention Type)
중재명칭(Intervention Name)
Patients with PAD demonstrated higher rates of late all-cause mortality, cardiovascular mortality, MI, and MACE than those without PAD.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
ICD 03