Jeong, So Yeong; Baek, Jung Hwan; Choi, Young Jun; Chung, Sae Rom; Sung, Tae Yon; Kim, Won Gu; Kim, Tae Yong; Lee, Jeong Hyun
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
2018Aug ; 34 ( 5 ) :611-616.
PMID : 29322881
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Jeong, So Yeong - a Department of Radiology and Research Institute of Radiology , Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea.
Baek, Jung Hwan - a Department of Radiology and Research Institute of Radiology , Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea.
Choi, Young Jun - a Department of Radiology and Research Institute of Radiology , Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea.
Chung, Sae Rom - a Department of Radiology and Research Institute of Radiology , Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea.
Sung, Tae Yon - b Department of Surgery , Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea.
Kim, Won Gu - c Department of Internal Medicine , Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea.
Kim, Tae Yong - c Department of Internal Medicine , Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea.
Lee, Jeong Hyun - a Department of Radiology and Research Institute of Radiology , Asan Medical Center, University of Ulsan College of Medicine , Seoul , Korea.
ABSTRACT
OBJECTIVE: To evaluate the efficacy of ultrasound (US)-guided radiofrequency ablation (RFA) according to the types of thyroid carcinoma, particularly in patients with a high-surgical risk. MATERIALS AND
METHODS: Eight patients with nine tumours of pathologically proven papillary and anaplastic carcinoma were treated by US-guided RFA. Patients with primary thyroid carcinoma were divided into three groups; group (1) Anaplastic carcinoma, group (2) papillary macrocarcinoma, and group (3) papillary microcarcinoma. We evaluated changes in clinical symptoms, tumour volume and local tumour recurrence/metastasis after RFA. Patients were followed up at 1, 6 and 12 months and annually thereafter.
RESULTS: Among nine tumours, one anaplastic carcinoma was treated three times and the other anaplastic carcinoma and one papillary macrocarcinoma were treated twice. Group 3 were treated once. The initial mean tumour volume was 107.9?±?78.6 (with neck bulging), 126.9 (with neck bulging) and 0.16?±?0.08?mL (without cosmetic or symptomatic problems) in groups 1-3, respectively. Group 1 showed no improvement in clinical symptoms or neck bulging after RFA, whereas group 2 demonstrated a decreased tumour volume measuring 0.7?mL with improved neck bulging. In group 3, mean volume decreased measuring 0.07?±?0.12?mL. No local tumour recurrence or metastatic lesion was detected during the mean follow-up of 19.3 months in papillary carcinomas. No major complications were encountered.
CONCLUSIONS: In patients with primary thyroid carcinoma, RFA achieved excellent local tumour control for papillary macro- and microcarcinoma; however, its clinical effect on anaplastic carcinoma was questionable.
keyword
Radiofrequency ablation; thyroid cancer; ultrasonography
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