Safety of radiofrequency ablation of benign thyroid nodules and recurrent thyroid cancers: a systematic review and meta-analysis.

Chung, Sae Rom; Suh, Chong Hyun; Baek, Jung Hwan; Park, Hye Sun; Choi, Young Jun; Lee, Jeong Hyun
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
2017Jun ; 13 ( 1 ) :1-11.
저자 상세정보
Chung, Sae Rom -
Suh, Chong Hyun -
Baek, Jung Hwan -
Park, Hye Sun -
Choi, Young Jun -
Lee, Jeong Hyun -
OBJECTIVE: We performed a systematic review and meta-analysis to evaluate the safety of radiofrequency ablation (RFA) for the treatment of benign thyroid nodules and recurrent thyroid cancers. MATERIALS AND

METHODS: Ovid-MEDLINE, EMBASE, and Library of Cochrane databases were searched up to 12 July 2016 for studies on the safety of RFA for treating benign thyroid nodules or recurrent thyroid cancers. Pooled proportions of overall and major complications were assessed using random-effects modelling. Heterogeneity among studies was determined using the ?(2) statistic for the pooled estimates and the inconsistency index I(2).

RESULTS: A total of 24 eligible studies were included, giving a sample size of 2421 patients and 2786 thyroid nodules. 41 major complications and 48 minor complications of RFA were reported, giving a pooled proportion of 2.38% for overall RFA complications [95% confidence interval (CI): 1.42%-3.34%] and 1.35% for major RFA complications (95% CI: 0.89%-1.81%). There were no heterogeneities in either overall or major complications (I(2)?=?1.24%-21.79%). On subgroup analysis, the overall and major complication rates were significantly higher for malignant thyroid nodules than for benign thyroid nodules (p?=?0.0011 and 0.0038, respectively).

CONCLUSIONS: RFA was found to be safe for the treatment of benign thyroid nodules and recurrent thyroid cancers.
Radiofrequency ablation; benign thyroid nodule; recurrent thyroid cancer; complication

주제명(Target field)
연구참여(Sample size)
질병특성(Condition Category)
연구설계(Study Design)
중재방법(Intervention Type)
중재명칭(Intervention Name)
RFA has an acceptable complication rate for the treatment of these conditions, although 41 major complications were reported, including voice change, nodule rupture, permanent hypothyroidism, and brachial plexus injury; the overall complication rate of RFA was 2.38% (95% CI: 1.42%–3.34%), and the rate of major complications was 1.35% (95% CI: 0.89%–1.81%). No patients had any life-threatening RFA-related complications.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
ICD 03