Radiofrequency ablation of benign thyroid nodules: depicting early sign of regrowth by calculating vital volume.

Sim, Jung Suk; Baek, Jung Hwan; Lee, Joongyub; Cho, Woojin; Jung, Sung Il
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
2017Apr ; 14 ( 4 ) :1-6.
저자 상세정보
Sim, Jung Suk -
Baek, Jung Hwan -
Lee, Joongyub -
Cho, Woojin -
Jung, Sung Il -
OBJECTIVE: We evaluated long-term follow-up results of radiofrequency ablation of benign thyroid nodules to analyse the role of marginal vital tissue on nodule regrowth. MATERIALS AND

METHODS: We reviewed the medical records of 54 patients who underwent radiofrequency ablation between June 2008 and November 2013 with pressure symptoms, and/or cosmetic problems. All patients were followed up at least 12?months on three occasions. To evaluate an early sign of regrowth, three types of nodule volumes (total volume, ablated volume and vital volume) were measured and calculated using ultrasonography. Regrowth was defined as a more than a 50% increase in the total volume and vital volume increase was defined as a more than 50% increase compared to the previously reported smallest volume on ultrasonography.

RESULTS: The mean follow-up period was 39.4?짹?21.7 (range, 13-87) months. Vital volume increases occurred in 31 nodules (57.4%) and there was regrowth in 13 nodules (24.1%). The mean timing of the vital volume increase was 27.5?짹?18.5?months, and for regrowth it was 39.9?짹?17.5?months. Vital volume increase tended to precede regrowth. CONCLUSION: Vital volume increase tended to occur earlier than regrowth and might be an early sign of regrowth in following-up after the radiofrequency ablation of benign thyroid nodules.
Radiofrequency/ microwave; thermal ablation; ultrasound; benign thyroid nodule; The overall complication rate was 3.6% (2/56), with one major and one minor complication.

주제명(Target field)
연구참여(Sample size)
질병특성(Condition Category)
연구설계(Study Design)
중재방법(Intervention Type)
중재명칭(Intervention Name)
The mean volume reduction ratio (VRR) after the first RFA was 77.0%.
연구비지원(Fund Source)
근거수준평가(Evidence Hierarchy)
ICD 03